Prevention of folate deficiency by food fortification. III. Effect in pregnant subjects of varying amounts of added folic acid

N. Colman, J. V. Larsen, M. Barker, E. A. Barker, Ralph Green, J. Metz

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Maize meal fortified with folic acid was administered to subjects in late pregnancy in a daily dose of either 500 or 300 μg of folic acid. Changes in hematological and folate nutritional status were compared to those in subjects receiving 300 μg folic acid/day in tablet form, and also in subjects in a previous study who received unfortified maize meal (control group) or meal containing 1,000 μg folic acid/day. In all groups receiving folic acid, red cell and serum folate levels rose progressively, and the rate of rise increased with increasing doses of folic acid. Maize meal containing a daily dose of 500 μg folic acid produced an effect similar to that of 300 μg daily in tablet form. Maize containing 300 μg added folic acid daily was effective in preventing the progression of folate depletion in late pregnancy.

Original languageEnglish (US)
Pages (from-to)465-470
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume28
Issue number5
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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