Prevention of diseases caused by Staphylococcus aureus using the peptide RIP

Naomi Balaban, L. Vincent Collins, James S Cullor, Emma B. Hume, Enrique Medina-Acosta, Olney Vieira da Motta, Richard O'Callaghan, Paul V. Rossitto, Mark E. Shirtliff, Leonardo Serafim da Silveira, Andrej Tarkowski, Jose V Torres

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Staphylococcus aureus causes many diseases including cellulitis, keratitis, osteomyelitis, septic arthritis and mastitis. The heptapeptide RIP has been shown to prevent cellulitis in mice, which was induced by S. aureus strain Smith diffuse. Here we show that RIP can also significantly reduce the overall pathology and delay the onset of disease symptoms in several other models of S. aureus infections, including: keratitis (tested in rabbits against S. aureus 8325-4), osteomyelitis (tested in rabbits against S. aureus MS), mastitis (tested in cows against S. aureus Newbould 305, AE-1, and environmental infections) and septic arthritis (tested in mice against S. aureus LS-1). These findings substantiate that RIP is not strain specific in its inhibitory activity and that RIP is an effective inhibitor of bacterial pathology at multiple body sites following diverse routes and doses of administration. These findings strongly evidence the potential value of RIP as a chemotherapeutic agent. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)1301-1311
Number of pages11
JournalPeptides
Volume21
Issue number9
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Prevention of diseases caused by Staphylococcus aureus using the peptide RIP'. Together they form a unique fingerprint.

  • Cite this

    Balaban, N., Collins, L. V., Cullor, J. S., Hume, E. B., Medina-Acosta, E., Vieira da Motta, O., O'Callaghan, R., Rossitto, P. V., Shirtliff, M. E., Serafim da Silveira, L., Tarkowski, A., & Torres, J. V. (2000). Prevention of diseases caused by Staphylococcus aureus using the peptide RIP. Peptides, 21(9), 1301-1311. https://doi.org/10.1016/S0196-9781(00)00272-2