Prevention early-onset gbs sepsis: implementation of the proposed CDC guidelines

Richard L Sweet, Beverly Brozanski, Faith Dibiasi, Judith Jones

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: The purpose of the study was to document the impact of the introduction into clinical practice of the proposed CDC guidelines for prevention of early onset GBS disease. Study Design: A retrospective study comparing the prevalence of early onset GBS sepsis (positive blood culture GBS) at Magee-Womens Hospital prior to the institution of CDC guidelines (January 1, 1992-June 30, 1995) with the prevalence of GBS sepsis following introduction of the CDC protocol (October 1, 1995-March 31, 1996). The microbiology laboratory data base was reviewed for all positive GBS blood cultures from the nursery, as were the medical records of blood culture GBS positive newboms. Results: From January 1, 1992-June 30, 1995 there were 36 cases of early onset GBS sepsis among 31,133 births for a rate of 1.15 per 1000 live births. After introduction of the CDC protocol there was 1 case of early onset GBS sepsis in 5500 births or 18 per 1000 live births (p=0.03). During these time periods the prevalence of maternal GBS vaginal colonization remained the same (27% vs 25%) By March, 1996 intrapartum prophylaxis for GBS was the most common new antibiotic order accounting for 36% of new antibiotic orders at MWH Post introduction of the CDC protocol, IV penicillin made up 83.2% of these orders, clindamycin 13.2%, erythromycin 0.5%, amyicillin 1.3% and other 1.8%. Conclusions: The proposed CDC guidelines for prevention of early onset GBS infection in newborns is very effective, reducing early onset GBS > 5-fold Institution of the CDC protocol was easily accomplished in a large community hospital where two-thirds of deliveries are by private attendings.

Original languageEnglish (US)
Pages (from-to)53-54
Number of pages2
JournalInfectious Diseases in Obstetrics and Gynecology
Volume4
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Centers for Disease Control and Prevention (U.S.)
Sepsis
Guidelines
Live Birth
Anti-Bacterial Agents
Clindamycin
Nurseries
Birth Rate
Community Hospital
Erythromycin
Microbiology
Penicillins
Medical Records
Retrospective Studies
Mothers
Parturition
Newborn Infant
Databases
Infection
Blood Culture

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Dermatology

Cite this

Prevention early-onset gbs sepsis : implementation of the proposed CDC guidelines. / Sweet, Richard L; Brozanski, Beverly; Dibiasi, Faith; Jones, Judith.

In: Infectious Diseases in Obstetrics and Gynecology, Vol. 4, No. 1, 1996, p. 53-54.

Research output: Contribution to journalArticle

Sweet, Richard L ; Brozanski, Beverly ; Dibiasi, Faith ; Jones, Judith. / Prevention early-onset gbs sepsis : implementation of the proposed CDC guidelines. In: Infectious Diseases in Obstetrics and Gynecology. 1996 ; Vol. 4, No. 1. pp. 53-54.
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