Abstract
Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 118-127 |
| Number of pages | 10 |
| Journal | Liver Research |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2019 |
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Keywords
- Biliary tract diseases
- Cirrhosis
- Inflammatory bowel disease (IBD)
- Metabolic bone disease
- Primary biliary cholangitis (PBC)
- Primary sclerosing cholangitis (PSC)
- Prophylaxis
- Pruritus
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Preventative care in cholestatic liver disease : Pearls for the specialist and subspecialist. / Malik, Adnan; Kardashian, Ani A.; Zakharia, Kais; Bowlus, Christopher L.; Tabibian, James H.
In: Liver Research, Vol. 3, No. 2, 06.2019, p. 118-127.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Preventative care in cholestatic liver disease
T2 - Pearls for the specialist and subspecialist
AU - Malik, Adnan
AU - Kardashian, Ani A.
AU - Zakharia, Kais
AU - Bowlus, Christopher L.
AU - Tabibian, James H.
PY - 2019/6
Y1 - 2019/6
N2 - Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.
AB - Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.
KW - Biliary tract diseases
KW - Cirrhosis
KW - Inflammatory bowel disease (IBD)
KW - Metabolic bone disease
KW - Primary biliary cholangitis (PBC)
KW - Primary sclerosing cholangitis (PSC)
KW - Prophylaxis
KW - Pruritus
UR - http://www.scopus.com/inward/record.url?scp=85073767516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073767516&partnerID=8YFLogxK
U2 - 10.1016/j.livres.2019.04.001
DO - 10.1016/j.livres.2019.04.001
M3 - Review article
AN - SCOPUS:85073767516
VL - 3
SP - 118
EP - 127
JO - Liver Research
JF - Liver Research
SN - 2542-5684
IS - 2
ER -