Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist

Adnan Malik; Ani A. Kardashian; Kais Zakharia; Christopher L. Bowlus; James Tabibian

doi:10.1016/j.livres.2019.04.001

Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist

Adnan Malik, Ani A. Kardashian, Kais Zakharia, Christopher L. Bowlus, James Tabibian

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article

Abstract

Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.

Original language	English (US)
Pages (from-to)	118-127
Number of pages	10
Journal	Liver Research
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.livres.2019.04.001
State	Published - Jun 2019

Keywords

Biliary tract diseases
Cirrhosis
Inflammatory bowel disease (IBD)
Metabolic bone disease
Primary biliary cholangitis (PBC)
Primary sclerosing cholangitis (PSC)
Prophylaxis
Pruritus

ASJC Scopus subject areas

Gastroenterology
Hepatology

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Malik, A., Kardashian, A. A., Zakharia, K., Bowlus, C. L., & Tabibian, J. (2019). Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist. Liver Research, 3(2), 118-127. https://doi.org/10.1016/j.livres.2019.04.001

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title = "Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist",

abstract = "Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.",

keywords = "Biliary tract diseases, Cirrhosis, Inflammatory bowel disease (IBD), Metabolic bone disease, Primary biliary cholangitis (PBC), Primary sclerosing cholangitis (PSC), Prophylaxis, Pruritus",

author = "Adnan Malik and Kardashian, {Ani A.} and Kais Zakharia and Bowlus, {Christopher L.} and James Tabibian",

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AU - Malik, Adnan

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AU - Bowlus, Christopher L.

AU - Tabibian, James

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N2 - Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.

AB - Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.

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KW - Cirrhosis

KW - Inflammatory bowel disease (IBD)

KW - Metabolic bone disease

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KW - Primary sclerosing cholangitis (PSC)

KW - Prophylaxis

KW - Pruritus

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