Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist

Adnan Malik, Ani A. Kardashian, Kais Zakharia, Christopher L. Bowlus, James Tabibian

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalLiver Research
Issue number2
StatePublished - Jun 2019
Externally publishedYes


  • Biliary tract diseases
  • Cirrhosis
  • Inflammatory bowel disease (IBD)
  • Metabolic bone disease
  • Primary biliary cholangitis (PBC)
  • Primary sclerosing cholangitis (PSC)
  • Prophylaxis
  • Pruritus

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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