Prevalence of sexual dimorphism in mammalian phenotypic traits

Natasha A. Karp, Jeremy Mason, Arthur L. Beaudet, Yoav Benjamini, Lynette Bower, Robert E. Braun, Steve D.M. Brown, Elissa J. Chesler, Mary E. DIckinson, Ann M. Flenniken, Helmut Fuchs, Martin Hrabe De Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J. Justice, Natalja Kurbatova, Christopher J. LelliottKevin C K Lloyd, Ann Marie Mallon, Judith E. Mank, Hiroshi Masuya, Colin McKerlie, Terrence F. Meehan, Richard F. Mott, Stephen A. Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R. Seavitt, Damian Smedley, Tania Sorg, Anneliese O. Speak, Karen P. Steel, Karen L. Svenson, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, Jacqueline K. White

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.

Original languageEnglish (US)
Article number15475
Pages (from-to)1DUMMY
JournalNature Communications
Volume8
DOIs
StatePublished - Jun 26 2017

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., DIckinson, M. E., Flenniken, A. M., Fuchs, H., Angelis, M. H. D., Gao, X., Guo, S., Greenaway, S., Heller, R., Herault, Y., Justice, M. J., Kurbatova, N., ... White, J. K. (2017). Prevalence of sexual dimorphism in mammalian phenotypic traits. Nature Communications, 8, 1DUMMY. [15475]. https://doi.org/10.1038/ncomms15475