Prevalence of serum antibodies against lymphocytic choriomeningitis virus in selected populations from two U.S. cities

C. B. Stephensen, S. R. Blount, R. E. Langford, K. V. Holmes, R. J. Montali, M. E. Fleenor, J. F E Shaw

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

An ELISA was developed for measuring serum antibodies against the arenavirus lymphocytic choriomeningitis virus (LCMV) and a closely related isolate termed callitrichid hepatitis virus (CHV). The ELISA was used to test sera from healthy adults and from hepatitis patients. In Birmingham, Alabama, the seropositivity rate for healthy black women was 5.1% (7/138), and the rate for patients with all types of hepatitis or cirrhosis was 4.3% (2/46). In San Antonio, Texas, the seropositivity rate among a clinical series of patients with non-A, non-B hepatitis was 0 (0/20), and the rate among persons rejected from blood donation because of high serum alanine aminotransferase levels was 2.4% (2/82). These results indicate that infection with LCMV or CHV is common in Birmingham but that infection is not associated with hepatitis.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalJournal of Medical Virology
Volume38
Issue number1
StatePublished - 1992
Externally publishedYes

Keywords

  • arenavirus
  • callitrichid
  • hepatitis

ASJC Scopus subject areas

  • Virology

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    Stephensen, C. B., Blount, S. R., Langford, R. E., Holmes, K. V., Montali, R. J., Fleenor, M. E., & Shaw, J. F. E. (1992). Prevalence of serum antibodies against lymphocytic choriomeningitis virus in selected populations from two U.S. cities. Journal of Medical Virology, 38(1), 27-31.