Prevalence of FMR1 repeat expansions in movement disorders: A systematic review

D. A. Hall, Randi J Hagerman, Paul J Hagerman, S. Jacquemont, M. A. Leehey

Research output: Contribution to journalArticle

26 Scopus citations


We reviewed prevalence rates of fragile X mental retardation gene (FMR1) repeat expansions in movement disorder populations. Inclusion criteria included published epidemiological studies from systematic searches of Medline, Pubmed, Cochrane Databases and Web Science. Thirteen cross-sectional studies were carried out between 2003 and 2005. Subjects with ataxia showed higher than expected rates while those with essential tremor and parkinsonism showed lower rates. The heterogeneous design of the studies, inclusion criteria and mean age of subjects may have led to underestimation of FMR1 repeat expansion prevalence rates.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
Issue number3
StatePublished - Apr 2006


  • Cerebellar ataxia
  • Fragile X syndrome
  • Fragile-X-associated tremor/ataxia syndrome
  • Parkinsonism

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

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