Prevalence of fluoroquinolone resistance among tuberculosis patients in Shanghai, China

Peng Xu, Xia Li, Ming Zhao, Xiaohong Gui, Kathryn DeRiemer, Sebastien Gagneux, Jian Mei, Qian Gao

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We determined the prevalence of fluoroquinolone resistance among the isolates of Mycobacterium tuberculosis from 605 pulmonary tuberculosis patients in Shanghai, China. Mutations in gyrA were found in 81.5% of phenotypically fluoroquinolone-resistant isolates and were used as a molecular marker of fluoroquinolone resistance. gyrA mutations were detected in 1.9% of strains pan-susceptible to first-line drugs and 25.1% of multidrug-resistant strains. Fluoroquinolone resistance was independently associated with resistance to at least one first-line drug and prior tuberculosis treatment.

Original languageEnglish (US)
Pages (from-to)3170-3172
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number7
DOIs
StatePublished - Jul 2009

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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    Xu, P., Li, X., Zhao, M., Gui, X., DeRiemer, K., Gagneux, S., Mei, J., & Gao, Q. (2009). Prevalence of fluoroquinolone resistance among tuberculosis patients in Shanghai, China. Antimicrobial Agents and Chemotherapy, 53(7), 3170-3172. https://doi.org/10.1128/AAC.00177-09