Prevalence of deficient retro-aortic rim and its effects on outcomes in device closure of atrial septal defects

Michael L. O'Byrne, Andrew C. Glatz, Sherzana Sunderji, Aswathi E. Mathew, David J. Goldberg, Yoav Dori, Jonathan J. Rome, Matthew J. Gillespie

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Deficient retro-aortic rim is of concern as a risk factor for aortic erosion after device closure of atrial septal defects (ASD). However, its prevalence and contribution to technical failure and adverse outcomes have not been delineated. A single-center retrospective cohort study of children and adults undergoing cardiac catheterization for device occlusion of ASD from 1 January 1999 to 1 April 2012 was performed. Risk factors for technical failure and early adverse outcome were assessed using multivariate logistic regression. During the study period, 445 consecutive subjects with a median age of 5.9 years (range, 0.8-80 years) underwent catheterization. Of the subjects with reviewable echocardiograms, 60 % had deficient retro-aortic rim. No attempt at device closure was made for 3.6 % of the subjects. Of the remaining 429 subjects, 96 % underwent successful device occlusion. Major early adverse events occurred in 1.2 % (95 % confidence interval 0.4-2.7 %) of the cases, all of them either device embolization or malposition. Deficient retro-aortic rim was not a risk factor for composite outcome of technical failure or early major adverse event. No deaths, late reinterventions, or erosion events occurred during 2,395 total person-years (median, 5.8 years) of follow-up evaluation. Deficient retro-aortic rim was associated with increased risk of device impingement on the aorta, but no association was seen between device impingement or deficient retro-aortic rim and the development of new/progressive aortic insufficiency. Deficient retro-aortic rim is highly prevalent but did not increase the risk of adverse outcomes. Its contribution to the risk of aortic erosion could not be addressed by this study.

Original languageEnglish (US)
Pages (from-to)1181-1190
Number of pages10
JournalPediatric Cardiology
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Keywords

  • Cardiac catheterization
  • Congenital
  • Heart defects
  • PEDS - pediatric interventions
  • Septal occluder device

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

O'Byrne, M. L., Glatz, A. C., Sunderji, S., Mathew, A. E., Goldberg, D. J., Dori, Y., Rome, J. J., & Gillespie, M. J. (2014). Prevalence of deficient retro-aortic rim and its effects on outcomes in device closure of atrial septal defects. Pediatric Cardiology, 1181-1190. https://doi.org/10.1007/s00246-014-0914-6