Prevalence of cavum septum pellucidum in schizophrenia studied with MRI

Rajaprabhakaran Rajarethinam, John Miedler, John DeQuardo, C. Irma Smet, James A Brunberg, Ravi Kirbat, Rajiv Tandon

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Objective: To study the prevalence of cavum septum pellucidum (CSP), a midline developmental anomaly, in patients with schizophrenia. Methods: Three-millimeter coronal T1 weighted MRI images of 43 normal controls and 73 patients with schizophrenia were examined. The images were resampled into 1-mm slices and CSP was measured by the number of slices in which it appeared. Results: Patients had significantly higher incidence of CSP (Fisher's exact test 0.042; one-sided). Eighteen (41.9%) of the controls and 44 (60.3%) of patients had a CSP, and one of 46 controls and three of 73 patients had a large CSP of six slices or more. There was no relationship between the presence or size of CSP and regional brain volumes or volumes of hippocampus-amygdala complex, caudate, superior temporal gyrus or ventricular CSF. Conclusion: Higher incidence of CSP may reflect a neurodevelopmental disturbance in schizophrenia.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalSchizophrenia Research
Issue number2-3
StatePublished - Mar 30 2001
Externally publishedYes


  • Cavum septum pellucidum
  • MRI
  • Neurodevelopmental
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)


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