Prevalence of bovine viral diarrhea virus infections in alpacas in the United States

Christina L. Topliff, David R. Smith, Sharon L. Clowser, David J. Steffen, Jamie N. Henningson, Bruce W. Brodersen, Daniela Bedenice, Robert J. Callan, Carlos Reggiardo, Kathy L. Kurth, Clayton L. Kelling

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective-To determine the prevalence of bovine viral diarrhea virus (BVDV)-infected alpaca herds in the United States and investigate factors associated with seropositive herd status and, subsequently, determine the proportion of animals within seropositive alpaca herds that are persistently infected (PI) carriers for BVDV, obtain information regarding previous herd exposure to BVDV, determine titers of anti-BVDV antibodies of dams, and ascertain whether individual seropositive crias had received supplemental colostrum at birth. Design-Prevalence study. Animals-63 alpaca herds with ≥ 12 registered female alpacas. Procedures-250 alpaca breeders were randomly selected from 562 eligible herds listed in the Alpaca Owner and Breeders Association membership directory and mailed a voluntary participation request. Sixty-three alpaca breeders participated in the study. From each herd, blood samples from > 4 crias were tested for BVDV, BVDV RNA, and serum neutralizing antibodies against BVDV. A region of the genome of BVDV recovered from PI crias was sequenced to determine genetic homology. Results-Among the 63 herds, 16 (25.4%) had seropositive crias and 4 (6.3%) had PI crias. Infections in 3 of the 4 herds with PI crias were linked as evidence by the genetic homologies of viruses. In addition to PI crias, feeding supplemental colostrum was associated with herd seropositivity. Conclusions and Clinical Relevance-Results confirmed the importance of BVDV infections in alpacas in the United States and highlighted the importance of determining the BVDV infection status of animals before they are commingled to limit exposure of herds to BVDV infection.

Original languageEnglish (US)
Pages (from-to)519-529
Number of pages11
JournalJournal of the American Veterinary Medical Association
Volume234
Issue number4
DOIs
StatePublished - Feb 15 2009
Externally publishedYes

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New World Camelids
Bovine Viral Diarrhea Viruses
alpacas
Bovine viral diarrhea virus
Virus Diseases
herds
infection
Colostrum
colostrum
Directories
animals
viral load
blood serum
Neutralizing Antibodies
dams (mothers)
Viral Load
neutralizing antibodies
seroprevalence
dietary supplements
Cross-Sectional Studies

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Topliff, C. L., Smith, D. R., Clowser, S. L., Steffen, D. J., Henningson, J. N., Brodersen, B. W., ... Kelling, C. L. (2009). Prevalence of bovine viral diarrhea virus infections in alpacas in the United States. Journal of the American Veterinary Medical Association, 234(4), 519-529. https://doi.org/10.2460/javma.234.4.519

Prevalence of bovine viral diarrhea virus infections in alpacas in the United States. / Topliff, Christina L.; Smith, David R.; Clowser, Sharon L.; Steffen, David J.; Henningson, Jamie N.; Brodersen, Bruce W.; Bedenice, Daniela; Callan, Robert J.; Reggiardo, Carlos; Kurth, Kathy L.; Kelling, Clayton L.

In: Journal of the American Veterinary Medical Association, Vol. 234, No. 4, 15.02.2009, p. 519-529.

Research output: Contribution to journalArticle

Topliff, CL, Smith, DR, Clowser, SL, Steffen, DJ, Henningson, JN, Brodersen, BW, Bedenice, D, Callan, RJ, Reggiardo, C, Kurth, KL & Kelling, CL 2009, 'Prevalence of bovine viral diarrhea virus infections in alpacas in the United States', Journal of the American Veterinary Medical Association, vol. 234, no. 4, pp. 519-529. https://doi.org/10.2460/javma.234.4.519
Topliff, Christina L. ; Smith, David R. ; Clowser, Sharon L. ; Steffen, David J. ; Henningson, Jamie N. ; Brodersen, Bruce W. ; Bedenice, Daniela ; Callan, Robert J. ; Reggiardo, Carlos ; Kurth, Kathy L. ; Kelling, Clayton L. / Prevalence of bovine viral diarrhea virus infections in alpacas in the United States. In: Journal of the American Veterinary Medical Association. 2009 ; Vol. 234, No. 4. pp. 519-529.
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abstract = "Objective-To determine the prevalence of bovine viral diarrhea virus (BVDV)-infected alpaca herds in the United States and investigate factors associated with seropositive herd status and, subsequently, determine the proportion of animals within seropositive alpaca herds that are persistently infected (PI) carriers for BVDV, obtain information regarding previous herd exposure to BVDV, determine titers of anti-BVDV antibodies of dams, and ascertain whether individual seropositive crias had received supplemental colostrum at birth. Design-Prevalence study. Animals-63 alpaca herds with ≥ 12 registered female alpacas. Procedures-250 alpaca breeders were randomly selected from 562 eligible herds listed in the Alpaca Owner and Breeders Association membership directory and mailed a voluntary participation request. Sixty-three alpaca breeders participated in the study. From each herd, blood samples from > 4 crias were tested for BVDV, BVDV RNA, and serum neutralizing antibodies against BVDV. A region of the genome of BVDV recovered from PI crias was sequenced to determine genetic homology. Results-Among the 63 herds, 16 (25.4{\%}) had seropositive crias and 4 (6.3{\%}) had PI crias. Infections in 3 of the 4 herds with PI crias were linked as evidence by the genetic homologies of viruses. In addition to PI crias, feeding supplemental colostrum was associated with herd seropositivity. Conclusions and Clinical Relevance-Results confirmed the importance of BVDV infections in alpacas in the United States and highlighted the importance of determining the BVDV infection status of animals before they are commingled to limit exposure of herds to BVDV infection.",
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