Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil

Marcia Ribeiro Andrade, Joann Yee, Peter A Barry, Abigail Spinner, Jeffrey A Roberts, Pedro H. Cabello, Jose Paulo Leite, Nicholas W. Lerche

Research output: Contribution to journalArticle

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Abstract

The rhesus macaque breeding colony of the Oswaldo Cruz Foundation (FIOCRUZ) was established in 1932 from a founding stock of 100 animals. This population has remained closed to new animal introductions for almost 70 years. A serologic survey was performed to determine the prevalence of antibodies to selected viruses as a first approach to identifying viral pathogens endemic in this population. Banked serum samples were tested for antibodies to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV), simian type D retrovirus (SRV), cercopithecine herpesvirus type-1 (B virus), rhesus cytomegalovirus (RhCMV), measles virus (MV), and hepatitis A virus (HAV). All samples were negative for antibodies against the simian retroviruses. The overall prevalence of antibodies was 95% for RhCMV, 45% for B virus, 35% for HAV, and 1% for MV. Prevalence was found to vary by age group. Am. J. Primatol.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalAmerican Journal of Primatology
Volume59
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

Macacine herpesvirus 1
Measles virus
Hepatitis A virus
Cytomegalovirus
breeding population
Macaca mulatta
seroprevalence
antibody
virus
Retroviridae
Betaretrovirus
Simian immunodeficiency virus
viruses
Brazil
antibodies
breeding
serological surveys
animals
sampling
measles

Keywords

  • Health monitoring
  • Nonhuman primates
  • Serological survey
  • Serology
  • Viruses

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil. / Andrade, Marcia Ribeiro; Yee, Joann; Barry, Peter A; Spinner, Abigail; Roberts, Jeffrey A; Cabello, Pedro H.; Leite, Jose Paulo; Lerche, Nicholas W.

In: American Journal of Primatology, Vol. 59, No. 3, 01.03.2003, p. 123-128.

Research output: Contribution to journalArticle

Andrade, Marcia Ribeiro ; Yee, Joann ; Barry, Peter A ; Spinner, Abigail ; Roberts, Jeffrey A ; Cabello, Pedro H. ; Leite, Jose Paulo ; Lerche, Nicholas W. / Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil. In: American Journal of Primatology. 2003 ; Vol. 59, No. 3. pp. 123-128.
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