Prevalence and Predictors of Anxiety Disorders in Adolescent and Adult Males with Autism Spectrum Disorder and Fragile X Syndrome

Jordan Ezell, Abigail Hogan, Amanda Fairchild, Kimberly Hills, Jessica Klusek, Leonard J Abbeduto, Jane Roberts

Research output: Contribution to journalArticle

4 Scopus citations


Anxiety disorders affect ~ 15–20% of youths without neurodevelopmental disorders, with persons having autism spectrum disorder (ASD) and fragile X syndrome (FXS) at elevated risk for anxiety disorders. Few studies have compared rates and predictors of anxiety disorders in adolescents with FXS or ASD. This study directly compares rates, predictors, and medication of anxiety disorders between age-matched, male adolescents with FXS (n = 31) or ASD (n = 20). Results indicate that 51.6% of FXS and 50.0% of ASD adolescents met criteria for an anxiety disorder. Cognitive scores and ASD severity did not predict anxiety. Of those with anxiety, ~ 40% of the FXS and 20% of the ASD participants were prescribed medications for anxiety.

Original languageEnglish (US)
JournalJournal of Autism and Developmental Disorders
StateAccepted/In press - Jan 1 2018



  • Anxiety
  • Autism spectrum disorder
  • Fragile X syndrome
  • Intellectual disability

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this