Prevalence and pathology of west nile virus in naturally infected house sparrows, Western Nebraska, 2008

Valerie A. O'Brien, Carol U. Meteyer, William Reisen, Hon S. Ip, Charles R. Brown

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Nestling birds are rarely sampled in the field for most arboviruses, yet they may be important in arbovirus amplification cycles. We sampled both nestling and adult house sparrows (Passer domesticus) in western Nebraska for West Nile virus (WNV) or WNV-specific antibodies throughout the summer of 2008 and describe pathology in naturally infected nestlings. Across the summer, 4% of nestling house sparrows were WNV-positive; for the month of August alone, 12.3% were positive. Two WNV-positive nestlings exhibited encephalitis, splenomegaly, hepatic necrosis, nephrosis, and myocarditis. One nestling sparrow had large mural thrombi in the atria and ventricle and immunohistochemical staining of WNV antigen in multiple organs including the wall of the aorta and pulmonary artery; cardiac insufficiency thus may have been a cause of death. Adult house sparrows showed an overall seroprevalence of 13.8% that did not change significantly across the summer months. The WNV-positive nestlings and the majority of seropositive adults were detected within separate spatial clusters. Nestling birds, especially those reared late in the summer when WNV activity is typically greatest, may be important in virus amplification.

Original languageEnglish (US)
Pages (from-to)937-944
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume82
Issue number5
DOIs
StatePublished - May 1 2010

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Sparrows
West Nile virus
Pathology
Arboviruses
Birds
Nephrosis
Splenomegaly
Myocarditis
Seroepidemiologic Studies
Encephalitis
Pulmonary Artery
Aorta
Cause of Death
Thrombosis
Necrosis
Staining and Labeling
Viruses
Antigens
Antibodies
Liver

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Prevalence and pathology of west nile virus in naturally infected house sparrows, Western Nebraska, 2008. / O'Brien, Valerie A.; Meteyer, Carol U.; Reisen, William; Ip, Hon S.; Brown, Charles R.

In: American Journal of Tropical Medicine and Hygiene, Vol. 82, No. 5, 01.05.2010, p. 937-944.

Research output: Contribution to journalArticle

O'Brien, Valerie A. ; Meteyer, Carol U. ; Reisen, William ; Ip, Hon S. ; Brown, Charles R. / Prevalence and pathology of west nile virus in naturally infected house sparrows, Western Nebraska, 2008. In: American Journal of Tropical Medicine and Hygiene. 2010 ; Vol. 82, No. 5. pp. 937-944.
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