Prevalence and outcomes of head and neck versus non-head and neck second primary malignancies in head and neck squamous cell carcinoma: An analysis of the surveillance, epidemiology, and end results database

Andrew C. Birkeland, Andrew J. Rosko, Steven B. Chinn, Mark E. Prince, Gordon H. Sun, Matthew E. Spector

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Aims: Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for second primary malignancies (SPMs). The prevalence, distribution, and patient survival in head and neck versus non-head and neck SPMs are not fully elucidated. The objective of this study was to quantify the rate of SPMs in patients with HNSCC. Methods: This is a population-based cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Prevalence and location of SPMs, and survival data were analyzed. Results: There were 58,363 HNSCC patients, and the prevalence of HNSCC and non-HNSCC SPMs was 3.0% (1,746) and 8.8% (5,109), respectively. Overall survival (OS) was higher in patients with HNSCC SPMs compared to non-HNSCC SPMs (p < 0.001), with no difference in disease-specific survival. Patients with SPMs in the lung and esophagus had a worse OS (p < 0.001), and patients with SPMs in the prostate and breast had a better OS (p < 0.001). Conclusion: In HNSCC patients who develop SPMs, nearly 75% are non-HNSCC SPMs. Patients with non-HNSCC SPMs have a lower OS. Future clinical practice guidelines should take the risks and locations of SPM development into consideration for screening.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalORL
Volume78
Issue number2
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

Second Primary Neoplasms
Epidemiology
Neck
Head
Databases
Survival
Squamous Cell Carcinoma
Carcinoma, squamous cell of head and neck
Practice Guidelines
Esophagus
Prostate
Breast
Cohort Studies

Keywords

  • Head and neck squamous cell carcinoma
  • Second primary malignancies
  • Surveillance, Epidemiology, and End Results database
  • Survival

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Prevalence and outcomes of head and neck versus non-head and neck second primary malignancies in head and neck squamous cell carcinoma : An analysis of the surveillance, epidemiology, and end results database. / Birkeland, Andrew C.; Rosko, Andrew J.; Chinn, Steven B.; Prince, Mark E.; Sun, Gordon H.; Spector, Matthew E.

In: ORL, Vol. 78, No. 2, 01.04.2016, p. 61-69.

Research output: Contribution to journalArticle

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abstract = "Background/Aims: Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for second primary malignancies (SPMs). The prevalence, distribution, and patient survival in head and neck versus non-head and neck SPMs are not fully elucidated. The objective of this study was to quantify the rate of SPMs in patients with HNSCC. Methods: This is a population-based cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Prevalence and location of SPMs, and survival data were analyzed. Results: There were 58,363 HNSCC patients, and the prevalence of HNSCC and non-HNSCC SPMs was 3.0{\%} (1,746) and 8.8{\%} (5,109), respectively. Overall survival (OS) was higher in patients with HNSCC SPMs compared to non-HNSCC SPMs (p < 0.001), with no difference in disease-specific survival. Patients with SPMs in the lung and esophagus had a worse OS (p < 0.001), and patients with SPMs in the prostate and breast had a better OS (p < 0.001). Conclusion: In HNSCC patients who develop SPMs, nearly 75{\%} are non-HNSCC SPMs. Patients with non-HNSCC SPMs have a lower OS. Future clinical practice guidelines should take the risks and locations of SPM development into consideration for screening.",
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