Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study

Kumar Rajan, Jennifer Weuve, Lisa L. Barnes, Robert S. Wilson, Denis A. Evans

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: The trends in prevalence and incidence of Alzheimer's disease (AD) dementia remain uncertain. Methods: A sample of 2794 participants with a clinical diagnosis for AD dementia were included. Results: The 2010 census standardized prevalence of AD dementia was 14.5% (95% CI = 13.7–15.3), and annual incidence was 2.3% (1.7–2.9). Both prevalence and incidence showed substantial variation over time, but no secular trends. The prevalence of AD dementia did not change significantly from 14.6% (95% CI = 13.0, 16.2) in 1994–1997 to 14.7% (95% CI = 13.2, 16.2) in 2010–2012 (P =.84). The annual incidence of AD dementia was 2.8% (95% CI = 2.2, 3.2) in 1998–2000 and 2.2% (95% CI = 1.6, 2.8) in 2004–2006 (P =.20) and remained steady in 2010–2012. The prevalence and incidence among African Americans were approximately twice than those among European Americans. Conclusions: The prevalence and incidence of AD dementia showed substantial variation between 1994 and 2012, but no secular trend.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Alzheimer Disease
Incidence
Population
Censuses
African Americans

Keywords

  • Dementia trends
  • Epidemiological study
  • Incidence
  • Prevalence

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study. / Rajan, Kumar; Weuve, Jennifer; Barnes, Lisa L.; Wilson, Robert S.; Evans, Denis A.

In: Alzheimer's and Dementia, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Introduction: The trends in prevalence and incidence of Alzheimer's disease (AD) dementia remain uncertain. Methods: A sample of 2794 participants with a clinical diagnosis for AD dementia were included. Results: The 2010 census standardized prevalence of AD dementia was 14.5{\%} (95{\%} CI = 13.7–15.3), and annual incidence was 2.3{\%} (1.7–2.9). Both prevalence and incidence showed substantial variation over time, but no secular trends. The prevalence of AD dementia did not change significantly from 14.6{\%} (95{\%} CI = 13.0, 16.2) in 1994–1997 to 14.7{\%} (95{\%} CI = 13.2, 16.2) in 2010–2012 (P =.84). The annual incidence of AD dementia was 2.8{\%} (95{\%} CI = 2.2, 3.2) in 1998–2000 and 2.2{\%} (95{\%} CI = 1.6, 2.8) in 2004–2006 (P =.20) and remained steady in 2010–2012. The prevalence and incidence among African Americans were approximately twice than those among European Americans. Conclusions: The prevalence and incidence of AD dementia showed substantial variation between 1994 and 2012, but no secular trend.",
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