Abstract
Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0-2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-147 |
| Number of pages | 5 |
| Journal | Pflügers Archiv European Journal of Physiology |
| Volume | 379 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1979 |
| Externally published | Yes |
Keywords
- C-fiber terminals
- Excitability testing
- Morphine
- Presynaptic inhibition
ASJC Scopus subject areas
- Physiology
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Carstens, E., Tulloch, I., Zieglgänsberger, W., & Zimmermann, M. (1979). Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers. Pflügers Archiv European Journal of Physiology, 379(2), 143-147. https://doi.org/10.1007/BF00586940