Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

Earl Carstens, I. Tulloch, W. Zieglgänsberger, M. Zimmermann

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0-2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalPflügers Archiv European Journal of Physiology
Volume379
Issue number2
DOIs
StatePublished - Mar 1979
Externally publishedYes

Keywords

  • C-fiber terminals
  • Excitability testing
  • Morphine
  • Presynaptic inhibition

ASJC Scopus subject areas

  • Physiology

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