Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

Earl Carstens; I. Tulloch; W. Zieglgänsberger; M. Zimmermann

doi:10.1007/BF00586940

Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

Earl Carstens, I. Tulloch, W. Zieglgänsberger, M. Zimmermann

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0-2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.

Original language	English (US)
Pages (from-to)	143-147
Number of pages	5
Journal	Pflügers Archiv European Journal of Physiology
Volume	379
Issue number	2
DOIs	https://doi.org/10.1007/BF00586940
State	Published - Mar 1979
Externally published	Yes

Keywords

C-fiber terminals
Excitability testing
Morphine
Presynaptic inhibition

ASJC Scopus subject areas

Physiology

Access to Document

10.1007/BF00586940

Fingerprint Dive into the research topics of 'Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers'. Together they form a unique fingerprint.

Cite this

@article{61a7829b944e4348970c6ed9482b20b5,

title = "Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers",

abstract = "Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0-2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.",

keywords = "C-fiber terminals, Excitability testing, Morphine, Presynaptic inhibition",

author = "Earl Carstens and I. Tulloch and W. Zieglg{\"a}nsberger and M. Zimmermann",

year = "1979",

month = mar,

doi = "10.1007/BF00586940",

language = "English (US)",

volume = "379",

pages = "143--147",

journal = "Pflugers Archiv European Journal of Physiology",

issn = "0031-6768",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

AU - Carstens, Earl

AU - Tulloch, I.

AU - Zieglgänsberger, W.

AU - Zimmermann, M.

PY - 1979/3

Y1 - 1979/3

N2 - Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0-2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.

AB - Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0-2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.

KW - C-fiber terminals

KW - Excitability testing

KW - Morphine

KW - Presynaptic inhibition

UR - http://www.scopus.com/inward/record.url?scp=0018389808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018389808&partnerID=8YFLogxK

U2 - 10.1007/BF00586940

DO - 10.1007/BF00586940

M3 - Article

C2 - 571108

AN - SCOPUS:0018389808

VL - 379

SP - 143

EP - 147

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - 2

ER -

Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this