Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

Earl Carstens; I. Tulloch; W. Zieglgänsberger; M. Zimmermann

doi:10.1007/BF00586940

Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

Earl Carstens, I. Tulloch, W. Zieglgänsberger, M. Zimmermann

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0-2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.

Original language	English (US)
Pages (from-to)	143-147
Number of pages	5
Journal	Pflügers Archiv European Journal of Physiology
Volume	379
Issue number	2
DOIs	https://doi.org/10.1007/BF00586940
State	Published - Mar 1979
Externally published	Yes

Keywords

C-fiber terminals
Excitability testing
Morphine
Presynaptic inhibition

ASJC Scopus subject areas

Physiology

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10.1007/BF00586940

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AU - Carstens, Earl

AU - Tulloch, I.

AU - Zieglgänsberger, W.

AU - Zimmermann, M.

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KW - Morphine

KW - Presynaptic inhibition

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