Presumptive pure erythroid leukemia in a dog

Mathios E. Mylonakis, Maria Kritsepi-Konstantinou, William Vernau, Victor E. Valli, Dimitra Pardali, Alexander F. Koutinas

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A 6.5-year-old, intact male Cocker Spaniel dog was referred with a history of depression and anorexia of 1-week duration. Mucosal pallor was prominent on physical examination. Complete blood cell count revealed pancytopenia and occasional blast cells. Bone marrow aspirate cytology indicated that individual particles were composed of approximately 60% hematopoietic cells and a monomorphic population of blast cells with perfectly round nuclei, consistent paranuclear clearing, and deeply basophilic cytoplasm devoid of granules dominating the marrow fields. The granulocytic lineage was severely decreased with a granulocytic-to-erythroid ratio of 0.15 and a blast cell percentage of at least 70% of all nucleated cells; the myeloblasts and monoblasts composed <5% of nonerythroid cells. Bone marrow cytology slides were submitted for immunocytochemical immunophenotyping using antibodies to myeloperoxidase, cluster of differentiation (CD)3, CD79a, CD11b, CD45, and CD34. The neoplastic cells did not express any of the antigens assessed. The combination of light microscopic cytomorphology and the immunophenotype were strongly suggestive of pure erythroid leukemia.

Original languageEnglish (US)
Pages (from-to)1004-1007
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume24
Issue number5
DOIs
StatePublished - Sep 2012

Keywords

  • Anemia
  • dogs
  • myeloid neoplasms
  • pure erythroid leukemia

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Presumptive pure erythroid leukemia in a dog'. Together they form a unique fingerprint.

  • Cite this

    Mylonakis, M. E., Kritsepi-Konstantinou, M., Vernau, W., Valli, V. E., Pardali, D., & Koutinas, A. F. (2012). Presumptive pure erythroid leukemia in a dog. Journal of Veterinary Diagnostic Investigation, 24(5), 1004-1007. https://doi.org/10.1177/1040638712452731