TY - JOUR
T1 - Presumptive Histiocytic Neoplasm with Unusual Immunophenotype in a Cat
AU - Mylonakis, Mathios E.
AU - Soubasis, Nektarios
AU - Kritsepi-Konstantinou, Maria
AU - Vernau, William
AU - Theodorou, Konstantina
AU - Tentoma, Lina
AU - Koutinas, Alexander F.
PY - 2012/4
Y1 - 2012/4
N2 - True histiocytic proliferative diseases have been infrequently documented in the cat, with progressive histiocytosis and histiocytic sarcoma representing the bulk of the reported cases. A 5-year-old, neutered male domestic shorthair cat presented with a 1-month history of anorexia, depression, mucosal pallor and persistent non regenerative anemia. On admission, the cat appeared depressed, icteric, dyspneic and had moderate splenomegaly. The cat had a severe, temporarily regenerative anemia, and a blood smear evaluation revealed numerous neutrophil- and monocyte-phagocytosed erythrocytes. Splenic and bone marrow aspirate smears were predominated by a monomorphic population of individual or aggregated round-to-oval cells, likely of histiocytic origin that often phagocytosed erythrocytes and leukocytes. A comprehensive immunocytochemical staining panel failed to definitively identify the neoplastic cells. This report emphasizes the clinical course, the sequential hematological abnormalities, the cytology and the unusual immunophenotype of a presumptive histiocytic sarcoma in a cat.
AB - True histiocytic proliferative diseases have been infrequently documented in the cat, with progressive histiocytosis and histiocytic sarcoma representing the bulk of the reported cases. A 5-year-old, neutered male domestic shorthair cat presented with a 1-month history of anorexia, depression, mucosal pallor and persistent non regenerative anemia. On admission, the cat appeared depressed, icteric, dyspneic and had moderate splenomegaly. The cat had a severe, temporarily regenerative anemia, and a blood smear evaluation revealed numerous neutrophil- and monocyte-phagocytosed erythrocytes. Splenic and bone marrow aspirate smears were predominated by a monomorphic population of individual or aggregated round-to-oval cells, likely of histiocytic origin that often phagocytosed erythrocytes and leukocytes. A comprehensive immunocytochemical staining panel failed to definitively identify the neoplastic cells. This report emphasizes the clinical course, the sequential hematological abnormalities, the cytology and the unusual immunophenotype of a presumptive histiocytic sarcoma in a cat.
KW - Cat
KW - Hemophagocytic histiocytic sarcoma
KW - Histiocytic proliferative diseases
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U2 - 10.1007/s00580-011-1304-6
DO - 10.1007/s00580-011-1304-6
M3 - Article
AN - SCOPUS:84859105138
VL - 21
SP - 231
EP - 236
JO - Comparative Clinical Pathology
JF - Comparative Clinical Pathology
SN - 1618-5641
IS - 2
ER -