Presumptive Histiocytic Neoplasm with Unusual Immunophenotype in a Cat

Mathios E. Mylonakis, Nektarios Soubasis, Maria Kritsepi-Konstantinou, William Vernau, Konstantina Theodorou, Lina Tentoma, Alexander F. Koutinas

Research output: Contribution to journalArticle

3 Scopus citations


True histiocytic proliferative diseases have been infrequently documented in the cat, with progressive histiocytosis and histiocytic sarcoma representing the bulk of the reported cases. A 5-year-old, neutered male domestic shorthair cat presented with a 1-month history of anorexia, depression, mucosal pallor and persistent non regenerative anemia. On admission, the cat appeared depressed, icteric, dyspneic and had moderate splenomegaly. The cat had a severe, temporarily regenerative anemia, and a blood smear evaluation revealed numerous neutrophil- and monocyte-phagocytosed erythrocytes. Splenic and bone marrow aspirate smears were predominated by a monomorphic population of individual or aggregated round-to-oval cells, likely of histiocytic origin that often phagocytosed erythrocytes and leukocytes. A comprehensive immunocytochemical staining panel failed to definitively identify the neoplastic cells. This report emphasizes the clinical course, the sequential hematological abnormalities, the cytology and the unusual immunophenotype of a presumptive histiocytic sarcoma in a cat.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalComparative Clinical Pathology
Issue number2
StatePublished - Apr 2012


  • Cat
  • Hemophagocytic histiocytic sarcoma
  • Histiocytic proliferative diseases

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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    Mylonakis, M. E., Soubasis, N., Kritsepi-Konstantinou, M., Vernau, W., Theodorou, K., Tentoma, L., & Koutinas, A. F. (2012). Presumptive Histiocytic Neoplasm with Unusual Immunophenotype in a Cat. Comparative Clinical Pathology, 21(2), 231-236.