Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985-2013)

K. Tomo Wiggans, Katherine A Skorupski, Christopher M. Reilly, Sara A. Frazier, Richard R. Dubielzig, David J Maggs

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective-To determine prevalence, reason for evaluation, treatment, and outcome for dogs and cats with presumed solitary ocular lymphoma (PSOL). Design-Retrospective case series. Animals-7 dogs and 2 cats with PSOL. Procedures-Medical records were reviewed. Progression-free survival time (PFST) and overall survival time (OST) were determined. Results-Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. Tumors included B-cell (2 intraocular and 1 conjunctival), non-B-cell, non-T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined. Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). All dogs with intraocular lymphoma developed neurologic signs. Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. Median PFST and OST were 178 days for all animals with PSOL, dogs with PSOL, and animals with intraocular lymphoma. Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively. Conclusions and Clinical Relevance-Results indicated PSOL was uncommon, but should be considered a differential diagnosis for animals with uveitis or conjunctivitis. Performance of MRI and cytologic analysis of CSF and regional lymph node aspirate samples may be beneficial for such patients. Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.

Original languageEnglish (US)
Pages (from-to)460-470
Number of pages11
JournalJournal of the American Veterinary Medical Association
Volume244
Issue number4
DOIs
StatePublished - Feb 15 2014

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lymphoma
Lymphoma
Cats
Dogs
cats
dogs
Intraocular Lymphoma
eyes
animals
Disease-Free Survival
Conjunctivitis
Uveitis
Conjunctival Neoplasms
conjunctivitis
Survival
Lymph Nodes
lymph nodes
Neurologic Manifestations
neoplasms
Medical Records

ASJC Scopus subject areas

  • veterinary(all)

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Presumed solitary intraocular or conjunctival lymphoma in dogs and cats : 9 cases (1985-2013). / Wiggans, K. Tomo; Skorupski, Katherine A; Reilly, Christopher M.; Frazier, Sara A.; Dubielzig, Richard R.; Maggs, David J.

In: Journal of the American Veterinary Medical Association, Vol. 244, No. 4, 15.02.2014, p. 460-470.

Research output: Contribution to journalArticle

Wiggans, K. Tomo ; Skorupski, Katherine A ; Reilly, Christopher M. ; Frazier, Sara A. ; Dubielzig, Richard R. ; Maggs, David J. / Presumed solitary intraocular or conjunctival lymphoma in dogs and cats : 9 cases (1985-2013). In: Journal of the American Veterinary Medical Association. 2014 ; Vol. 244, No. 4. pp. 460-470.
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