Abstract
An unusual form of cerebellar granuloprival degeneration was observed in three male Coton de Tulear puppies between 12 and 14 weeks of age from different litters showing progressive cerebellar signs beginning at 8 weeks after birth. Pathological examinations revealed a shrunken cerebellum. Histopathologically the granular cells were diminished or almost completely absent, some 'torpedos' of Purkinje cells were present. There was a marked gliosis, and occasionally small inflammatory foci were present. A marked diffuse T cell infiltration (CD3+ cells) occurred in the lesions, B cells did not appear. CD18 staining showed an upregulation of microglial cells at the lesion site. Histopathologically the lesions resembled paraneoplastic cerebellar degeneration which is caused by an autoimmune mediated T cell reaction. This congenital condition in the Coton de Tulear dog breed could be based on a genetically defined immune defect leading to autoimmune destruction of the granular cells. (C) 2000 Elsevier Science B.V.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 130-133 |
| Number of pages | 4 |
| Journal | Journal of Neuroimmunology |
| Volume | 110 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Oct 2 2000 |
| Externally published | Yes |
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Keywords
- Cerebellar granuloprival degeneration
- Coton de Tulear breed
- Microglia
- T cells
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology
Cite this
Presumed immune-mediated cerebellar granuloprival degeneration in the Coton de Tulear breed. / Tipold, A.; Fatzer, R.; Jaggy, A.; Moore, Peter F; Vandevelde, M.
In: Journal of Neuroimmunology, Vol. 110, No. 1-2, 02.10.2000, p. 130-133.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presumed immune-mediated cerebellar granuloprival degeneration in the Coton de Tulear breed
AU - Tipold, A.
AU - Fatzer, R.
AU - Jaggy, A.
AU - Moore, Peter F
AU - Vandevelde, M.
PY - 2000/10/2
Y1 - 2000/10/2
N2 - An unusual form of cerebellar granuloprival degeneration was observed in three male Coton de Tulear puppies between 12 and 14 weeks of age from different litters showing progressive cerebellar signs beginning at 8 weeks after birth. Pathological examinations revealed a shrunken cerebellum. Histopathologically the granular cells were diminished or almost completely absent, some 'torpedos' of Purkinje cells were present. There was a marked gliosis, and occasionally small inflammatory foci were present. A marked diffuse T cell infiltration (CD3+ cells) occurred in the lesions, B cells did not appear. CD18 staining showed an upregulation of microglial cells at the lesion site. Histopathologically the lesions resembled paraneoplastic cerebellar degeneration which is caused by an autoimmune mediated T cell reaction. This congenital condition in the Coton de Tulear dog breed could be based on a genetically defined immune defect leading to autoimmune destruction of the granular cells. (C) 2000 Elsevier Science B.V.
AB - An unusual form of cerebellar granuloprival degeneration was observed in three male Coton de Tulear puppies between 12 and 14 weeks of age from different litters showing progressive cerebellar signs beginning at 8 weeks after birth. Pathological examinations revealed a shrunken cerebellum. Histopathologically the granular cells were diminished or almost completely absent, some 'torpedos' of Purkinje cells were present. There was a marked gliosis, and occasionally small inflammatory foci were present. A marked diffuse T cell infiltration (CD3+ cells) occurred in the lesions, B cells did not appear. CD18 staining showed an upregulation of microglial cells at the lesion site. Histopathologically the lesions resembled paraneoplastic cerebellar degeneration which is caused by an autoimmune mediated T cell reaction. This congenital condition in the Coton de Tulear dog breed could be based on a genetically defined immune defect leading to autoimmune destruction of the granular cells. (C) 2000 Elsevier Science B.V.
KW - Cerebellar granuloprival degeneration
KW - Coton de Tulear breed
KW - Microglia
KW - T cells
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UR - http://www.scopus.com/inward/citedby.url?scp=0034597042&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(00)00330-1
DO - 10.1016/S0165-5728(00)00330-1
M3 - Article
C2 - 11024542
AN - SCOPUS:0034597042
VL - 110
SP - 130
EP - 133
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -