Prestress due to dimensional changes caused by demineralization: A potential mechanism for microcracking in bone

Yener N. Yeni, Mitchell B. Schaffler, Gary Gibson, David P Fyhrie

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A series of experiments were carried out to gain more insight into mineralization-related strains in bone by studying the inverse problem of dimensional changes related to demineralization. Focus was on different anatomical orientations in miniaturized specimens of human and chemically altered bovine bone. Significant strains upon demineralization were observed. The strains indicate mechanisms of matrix expansion during mineralization consistent with observed in vivo microcracking patterns.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalAnnals of Biomedical Engineering
Volume30
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Anisotropy
  • Collagen cross-linking
  • Cortical bone
  • Demineralization prestress
  • Glycation
  • Microcracking

ASJC Scopus subject areas

  • Biomedical Engineering

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