Pressure regulator for robust gel injection in coupling microfluidic chip for 3D microvascular tissue

X. Wang, D. Phan, Steven George, C. C.W. Hughes, A. P. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports a novel pressure regulator design that can facilitate the stable gel injection into specific region with well-controlled gel interface without bursting. This design can be integrated into any microfluidic chip used for gel loading and is compatible with a wide variety of injection equipment operated by either automatic or manual mode at different injection flow rates. The effectiveness of this pressure regulator is confirmed by its incorporation into a coupling microfluidic chip for 3D microvascular tissue formation. The reproducible and robust injection performance is demonstrated by both automatic dye-mixed gel loading with syringe pump and manual cell-seeded gel loading with pipette.

Original languageEnglish (US)
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages740-742
Number of pages3
ISBN (Electronic)9780979806483
StatePublished - Jan 1 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

Fingerprint

Pressure regulators
Microfluidics
Gels
Tissue
Syringes
Dyes
Flow rate
Pumps

Keywords

  • Gel injection
  • Microfluidic chip
  • Pressure regulator

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Wang, X., Phan, D., George, S., Hughes, C. C. W., & Lee, A. P. (2015). Pressure regulator for robust gel injection in coupling microfluidic chip for 3D microvascular tissue. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 740-742). Chemical and Biological Microsystems Society.

Pressure regulator for robust gel injection in coupling microfluidic chip for 3D microvascular tissue. / Wang, X.; Phan, D.; George, Steven; Hughes, C. C.W.; Lee, A. P.

MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. p. 740-742.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, X, Phan, D, George, S, Hughes, CCW & Lee, AP 2015, Pressure regulator for robust gel injection in coupling microfluidic chip for 3D microvascular tissue. in MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 740-742, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, Gyeongju, Korea, Republic of, 10/25/15.
Wang X, Phan D, George S, Hughes CCW, Lee AP. Pressure regulator for robust gel injection in coupling microfluidic chip for 3D microvascular tissue. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2015. p. 740-742
Wang, X. ; Phan, D. ; George, Steven ; Hughes, C. C.W. ; Lee, A. P. / Pressure regulator for robust gel injection in coupling microfluidic chip for 3D microvascular tissue. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. pp. 740-742
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