Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord

Michael K C Wong, Janeen M. Hill, Marc P Kaufman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Microinjection ofl-glutamate (109 mM; 12-18nl) or AMPA (150-300 μM; 12 nl) into the superficial laminae of the L7 dorsal horn of decerebrate or chloralose anesthetized cats significantly increased mean arterial pressure. In contrast, microinjection of NMDA (300 μM; 12 nl) had no effect on mean arterial pressure. The pressor response tol-glutamate microinjection was blocked by prior microinjection of CNQX, an antagonist to non-NMDA receptors, but not by AP-5, an antagonist to NMDA receptors. We conclude that stimulation of non-NMDA receptors in the superficial laminae of the lumbar dorsal horn increases arterial blood pressure.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalBrain Research
Volume683
Issue number1
DOIs
StatePublished - Jun 12 1995

Keywords

  • Autonomic nervous system
  • Dorsal horn
  • Excitatory amino acid receptor
  • Ventilation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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