Pressor reflex response to static muscular contraction: Its afferent arm and possible neurotransmitters

Marc P Kaufman, Diane M. Rotto, Kenneth J. Rybicki

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Static muscular contraction has been shown to increase cardiovascular and ventilatory function in reflex manner. The sensory arm of this reflex arc is comprised of group III and IV muscle afferents. The discharge properties of these muscle afferents whose activation causes the pressor reflex response to contraction were investigated. Group III afferents were more responsive to mechanical stimuli, such as tendon stretch and probing their receptive fields than were group IV afferents. In contrast, group III afferents were less responsive to ischemic contraction than were group IV afferents. Equal percentages of group III and IV afferents were stimulated by potassium, lactic acid and arachidonic acid, each of which are metabolic products of contraction. Adenosine, phosphate and lactate, however, had no effect on the discharge of the afferents. Intrathecal injection of antagonists or antibodies to substance P and somatostatin attenuated the pressor response to contraction by about half, a finding that suggests a role for these 2 peptides in the spinal transmission of the reflex.

Original languageEnglish (US)
JournalThe American journal of cardiology
Volume62
Issue number8
DOIs
StatePublished - Sep 9 1988

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Muscle Contraction
Neurotransmitter Agents
Reflex
Lactic Acid
Spinal Injections
Muscles
Adenine Nucleotides
Substance P
Somatostatin
Arachidonic Acid
Tendons
Potassium
Peptides
Antibodies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pressor reflex response to static muscular contraction : Its afferent arm and possible neurotransmitters. / Kaufman, Marc P; Rotto, Diane M.; Rybicki, Kenneth J.

In: The American journal of cardiology, Vol. 62, No. 8, 09.09.1988.

Research output: Contribution to journalArticle

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