Pressor reflex evoked by muscular contraction: Contributions by neuraxis levels

G. A. Iwamoto, T. G. Waldrop, Marc P Kaufman, B. R. Botterman, K. J. Rybicki, J. H. Mitchell

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Abstract

The pressor reflex evoked by muscular contraction (exercise pressor reflex) is one important model of cardiovascular adjustments during static exercise. The central nervous system (CNS) structures mediating this reflex have remained largely obscure. Therefore, we examined the contribution of selected levels of the neuraxis in mediating the pressor reflex evoked by muscular contraction from stimulation of ventral roots. Decerebrate cats exhibited larger pressor reflexes than those found in intact α-chloralose-anesthetized cats, a difference more apparent at low (5 Hz or repeated twitch) rather than at high (50 Hz or tetanic) stimulus frequencies. Although a depressor response to 5-Hz stimulation was observed in the intact anesthetized cats, it appeared to be primarily due to anesthetic level, since a depressor response was not observed in decerebrate animals (nonanesthetized). Cerebellectomy produced no changes in the reflexes of the decerebrate animal. Further transection of the neuraxis (caudal to the midcollicular level) attenuated the exercise pressor reflex. The spinal cat demonstrated slight evidence of exercise pressor reflex activity. These results provide clarification as to representation of this pressor reflex within the CNS and establish the reflex's characteristics at several levels of neuraxis integration.

Original languageEnglish (US)
Pages (from-to)459-467
Number of pages9
JournalJournal of Applied Physiology
Volume59
Issue number2
StatePublished - 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Iwamoto, G. A., Waldrop, T. G., Kaufman, M. P., Botterman, B. R., Rybicki, K. J., & Mitchell, J. H. (1985). Pressor reflex evoked by muscular contraction: Contributions by neuraxis levels. Journal of Applied Physiology, 59(2), 459-467.