Preserving function in Duchenne dystrophy with long-term pulse prednisone therapy

Gregory T. Carter, Craig M McDonald

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Carter GT, McDonald CM: Preserving function in Duchenne dystrophy with long-term pulse prednisone therapy. Am J Phys Med Rehabil 2000;79:455-458. We report a case of a patient with Duchenne muscular dystrophy who was treated with intermittent pulse prednisone for severe asthma from age 3 to 17 yr and had remarkable preservation of skeletal muscle function. He had a maternal uncle with Duchenne muscular dystrophy who had the identical familial deletion mutation and died at age 19 of respiratory failure. Compared with his untreated uncle, our patient remains partially ambulatory at age 20. This case provides interesting, albeit anecdotal, evidence of considerable clinical benefit from pulse prednisone used on a much longer term basis than has been previously studied and promotes the need for further investigation on this type of therapy in Duchenne muscular dystrophy.

Original languageEnglish (US)
Pages (from-to)455-458
Number of pages4
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume79
Issue number5
StatePublished - Sep 2000

Keywords

  • Duchenne Muscular Dystrophy
  • Impairment
  • Neuromuscular Disease
  • Prednisone
  • Strength

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Health Professions(all)
  • Physical Therapy, Sports Therapy and Rehabilitation

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