Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys

A. H. Gazzaley, M. M. Thakker, P. R. Hof, John Morrison

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The perforant path, which consists of the projection from the layer II neurons of the entorhinal cortex to the outer molecular layer of the dentate gyrus, is a critical circuit involved in learning and memory formation. Accordingly, disturbances in this circuit may contribute to age-related cognitive deficits. In a previous study, we demonstrated a decrease in N-methyl-D-aspartate receptor subunit 1 immunofluorescence intensity in the outer molecular layer of aged macaque monkeys. In this study, we used the optical fractionator, a stereological method, to determine if a loss of layer II neurons occurred in the same animals in which the N-methyl-D-aspartate receptor subunit 1 alteration was observed. Our results revealed no significant differences in the number of layer II neurons between juvenile, young adult, and aged macaque monkeys. These results suggest that the circuit-specific decrease in N-methyl-D-aspartate receptor subunit 1 reported previously occurs in the absence of structural compromise of (he perforant path, and thus may be linked to an age-related change in the physiological properties of this circuit.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalNeurobiology of Aging
Volume18
Issue number5
DOIs
StatePublished - Sep 1 1997
Externally publishedYes

Fingerprint

Entorhinal Cortex
Macaca
N-Methyl-D-Aspartate Receptors
Perforant Pathway
Haplorhini
Neurons
Dentate Gyrus
Fluorescent Antibody Technique
Young Adult
Learning

Keywords

  • Aging
  • Entorhinal cortex
  • Macaque monkey
  • Optical fractionator
  • Stereology

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. / Gazzaley, A. H.; Thakker, M. M.; Hof, P. R.; Morrison, John.

In: Neurobiology of Aging, Vol. 18, No. 5, 01.09.1997, p. 549-553.

Research output: Contribution to journalArticle

Gazzaley, A. H. ; Thakker, M. M. ; Hof, P. R. ; Morrison, John. / Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. In: Neurobiology of Aging. 1997 ; Vol. 18, No. 5. pp. 549-553.
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