Presence of vasomotor symptoms is associated with lower bone mineral density: A longitudinal analysis

Carolyn J. Crandall, Yan Zheng, Sybil L. Crawford, Rebecca C. Thurston, Ellen B Gold, Janet M. Johnston, Gail A. Greendale

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective: To determine whether women with vasomotor symptoms (VMS) have lower bone mineral density (BMD) than do women without VMS. Methods: We analyzed data from baseline to annual follow-up visit 5 for 2,213 participants in the bone substudy of the Study of Women's Health Across the Nation. At baseline, women were aged 42 to 52 years, had an intact uterus and one or more ovaries, were not using exogenous hormones, were not pregnant or lactating, and were premenopausal or early perimenopausal. Menopausal stage and VMS were assessed by annual questionnaire. Menopausal stages were premenopausal, early perimenopausal, late perimenopausal, and postmenopausal. Using repeated-measures mixed models, we determined the association between VMS (any vs none) and BMD (by dual x-ray absorptiometry) within each menopause status category. Results: After controlling for age, time within each menopausal stage, race/ethnicity, study site, and baseline menopausal stage, postmenopausal women with any VMS had lower lumbar (0.008 g/cm 2 lower, P = 0.001) and lower total hip (0.005 g/cm 2 lower, P = 0.04) BMD than did postmenopausal women without VMS. Compared with early perimenopausal women without VMS, early perimenopausal women with any VMS had lower femoral neck BMD (0.003 g/cm 2 lower, P = 0.0001). Premenopausal women with any VMS had lower femoral neck BMD (0.003 g/cm 2 lower, P = 0.03) compared with premenopausal women without VMS. Conclusions: Even in the earliest menopausal transition stages, women with VMS had lower BMD than did women without VMS. Effects varied by anatomical site, being most evident at the lumbar spine and total hip in postmenopausal women and at the femoral neck among premenopausal and early perimenopausal women.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalMenopause
Volume16
Issue number2
DOIs
StatePublished - Mar 2009

Fingerprint

Bone Density
Femur Neck
Hip
Women's Health
Menopause
Uterus
Ovary
Spine
X-Rays
Hormones
Bone and Bones

Keywords

  • Bone mineral density
  • Hot flashes
  • Menopause
  • Vasomotor symptoms

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Crandall, C. J., Zheng, Y., Crawford, S. L., Thurston, R. C., Gold, E. B., Johnston, J. M., & Greendale, G. A. (2009). Presence of vasomotor symptoms is associated with lower bone mineral density: A longitudinal analysis. Menopause, 16(2), 239-246. https://doi.org/10.1097/gme.0b013e3181857964

Presence of vasomotor symptoms is associated with lower bone mineral density : A longitudinal analysis. / Crandall, Carolyn J.; Zheng, Yan; Crawford, Sybil L.; Thurston, Rebecca C.; Gold, Ellen B; Johnston, Janet M.; Greendale, Gail A.

In: Menopause, Vol. 16, No. 2, 03.2009, p. 239-246.

Research output: Contribution to journalArticle

Crandall, CJ, Zheng, Y, Crawford, SL, Thurston, RC, Gold, EB, Johnston, JM & Greendale, GA 2009, 'Presence of vasomotor symptoms is associated with lower bone mineral density: A longitudinal analysis', Menopause, vol. 16, no. 2, pp. 239-246. https://doi.org/10.1097/gme.0b013e3181857964
Crandall, Carolyn J. ; Zheng, Yan ; Crawford, Sybil L. ; Thurston, Rebecca C. ; Gold, Ellen B ; Johnston, Janet M. ; Greendale, Gail A. / Presence of vasomotor symptoms is associated with lower bone mineral density : A longitudinal analysis. In: Menopause. 2009 ; Vol. 16, No. 2. pp. 239-246.
@article{ec24fca7bbbb4b9b9ac33defda512e9d,
title = "Presence of vasomotor symptoms is associated with lower bone mineral density: A longitudinal analysis",
abstract = "Objective: To determine whether women with vasomotor symptoms (VMS) have lower bone mineral density (BMD) than do women without VMS. Methods: We analyzed data from baseline to annual follow-up visit 5 for 2,213 participants in the bone substudy of the Study of Women's Health Across the Nation. At baseline, women were aged 42 to 52 years, had an intact uterus and one or more ovaries, were not using exogenous hormones, were not pregnant or lactating, and were premenopausal or early perimenopausal. Menopausal stage and VMS were assessed by annual questionnaire. Menopausal stages were premenopausal, early perimenopausal, late perimenopausal, and postmenopausal. Using repeated-measures mixed models, we determined the association between VMS (any vs none) and BMD (by dual x-ray absorptiometry) within each menopause status category. Results: After controlling for age, time within each menopausal stage, race/ethnicity, study site, and baseline menopausal stage, postmenopausal women with any VMS had lower lumbar (0.008 g/cm 2 lower, P = 0.001) and lower total hip (0.005 g/cm 2 lower, P = 0.04) BMD than did postmenopausal women without VMS. Compared with early perimenopausal women without VMS, early perimenopausal women with any VMS had lower femoral neck BMD (0.003 g/cm 2 lower, P = 0.0001). Premenopausal women with any VMS had lower femoral neck BMD (0.003 g/cm 2 lower, P = 0.03) compared with premenopausal women without VMS. Conclusions: Even in the earliest menopausal transition stages, women with VMS had lower BMD than did women without VMS. Effects varied by anatomical site, being most evident at the lumbar spine and total hip in postmenopausal women and at the femoral neck among premenopausal and early perimenopausal women.",
keywords = "Bone mineral density, Hot flashes, Menopause, Vasomotor symptoms",
author = "Crandall, {Carolyn J.} and Yan Zheng and Crawford, {Sybil L.} and Thurston, {Rebecca C.} and Gold, {Ellen B} and Johnston, {Janet M.} and Greendale, {Gail A.}",
year = "2009",
month = "3",
doi = "10.1097/gme.0b013e3181857964",
language = "English (US)",
volume = "16",
pages = "239--246",
journal = "Menopause",
issn = "1072-3714",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Presence of vasomotor symptoms is associated with lower bone mineral density

T2 - A longitudinal analysis

AU - Crandall, Carolyn J.

AU - Zheng, Yan

AU - Crawford, Sybil L.

AU - Thurston, Rebecca C.

AU - Gold, Ellen B

AU - Johnston, Janet M.

AU - Greendale, Gail A.

PY - 2009/3

Y1 - 2009/3

N2 - Objective: To determine whether women with vasomotor symptoms (VMS) have lower bone mineral density (BMD) than do women without VMS. Methods: We analyzed data from baseline to annual follow-up visit 5 for 2,213 participants in the bone substudy of the Study of Women's Health Across the Nation. At baseline, women were aged 42 to 52 years, had an intact uterus and one or more ovaries, were not using exogenous hormones, were not pregnant or lactating, and were premenopausal or early perimenopausal. Menopausal stage and VMS were assessed by annual questionnaire. Menopausal stages were premenopausal, early perimenopausal, late perimenopausal, and postmenopausal. Using repeated-measures mixed models, we determined the association between VMS (any vs none) and BMD (by dual x-ray absorptiometry) within each menopause status category. Results: After controlling for age, time within each menopausal stage, race/ethnicity, study site, and baseline menopausal stage, postmenopausal women with any VMS had lower lumbar (0.008 g/cm 2 lower, P = 0.001) and lower total hip (0.005 g/cm 2 lower, P = 0.04) BMD than did postmenopausal women without VMS. Compared with early perimenopausal women without VMS, early perimenopausal women with any VMS had lower femoral neck BMD (0.003 g/cm 2 lower, P = 0.0001). Premenopausal women with any VMS had lower femoral neck BMD (0.003 g/cm 2 lower, P = 0.03) compared with premenopausal women without VMS. Conclusions: Even in the earliest menopausal transition stages, women with VMS had lower BMD than did women without VMS. Effects varied by anatomical site, being most evident at the lumbar spine and total hip in postmenopausal women and at the femoral neck among premenopausal and early perimenopausal women.

AB - Objective: To determine whether women with vasomotor symptoms (VMS) have lower bone mineral density (BMD) than do women without VMS. Methods: We analyzed data from baseline to annual follow-up visit 5 for 2,213 participants in the bone substudy of the Study of Women's Health Across the Nation. At baseline, women were aged 42 to 52 years, had an intact uterus and one or more ovaries, were not using exogenous hormones, were not pregnant or lactating, and were premenopausal or early perimenopausal. Menopausal stage and VMS were assessed by annual questionnaire. Menopausal stages were premenopausal, early perimenopausal, late perimenopausal, and postmenopausal. Using repeated-measures mixed models, we determined the association between VMS (any vs none) and BMD (by dual x-ray absorptiometry) within each menopause status category. Results: After controlling for age, time within each menopausal stage, race/ethnicity, study site, and baseline menopausal stage, postmenopausal women with any VMS had lower lumbar (0.008 g/cm 2 lower, P = 0.001) and lower total hip (0.005 g/cm 2 lower, P = 0.04) BMD than did postmenopausal women without VMS. Compared with early perimenopausal women without VMS, early perimenopausal women with any VMS had lower femoral neck BMD (0.003 g/cm 2 lower, P = 0.0001). Premenopausal women with any VMS had lower femoral neck BMD (0.003 g/cm 2 lower, P = 0.03) compared with premenopausal women without VMS. Conclusions: Even in the earliest menopausal transition stages, women with VMS had lower BMD than did women without VMS. Effects varied by anatomical site, being most evident at the lumbar spine and total hip in postmenopausal women and at the femoral neck among premenopausal and early perimenopausal women.

KW - Bone mineral density

KW - Hot flashes

KW - Menopause

KW - Vasomotor symptoms

UR - http://www.scopus.com/inward/record.url?scp=67649345968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649345968&partnerID=8YFLogxK

U2 - 10.1097/gme.0b013e3181857964

DO - 10.1097/gme.0b013e3181857964

M3 - Article

C2 - 19002017

AN - SCOPUS:67649345968

VL - 16

SP - 239

EP - 246

JO - Menopause

JF - Menopause

SN - 1072-3714

IS - 2

ER -