Preputial cellular and antibody responses of bulls vaccinated and/or challenged with Tritrichomonas foetus

Eduardo R. Cobo, Lynette B. Corbeil, Laurel J Gershwin, Robert Bondurant

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Systemic and genital immune responses in bulls were determined after infection with Tritrichomonas foetus and systemic vaccination with whole cell antigens. Vaccinated bulls resisted infection, developed IgG1 and IgG2 antibodies against T. foetus in preputial secretions and serum, and had increased MHC II+ and CD205+ cells (probably dendritic cells), CD3+ and CD8+ T cells, and B cells including IgG1 and IgA plasma cells in the prepuce. Non-vaccinated bulls challenged with T. foetus were persistently infected and had no detectable antibodies to T. foetus in either preputial secretions or serum for 6 weeks post challenge. We conclude that genital and serum IgG antibodies to T. foetus accounts for resistance of vaccinated bulls to T. foetus infection and that the lack of an antibody response in infected bulls accounts for persistent infection.

Original languageEnglish (US)
Pages (from-to)361-370
Number of pages10
JournalVaccine
Volume28
Issue number2
DOIs
StatePublished - Dec 11 2009

Keywords

  • Bovine genital immunity
  • Tritrichomonas foetus
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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