Preparation of nonracemic 3,5-disubstituted-γ-butyrolactones: An effective sequent auxiliary for amide alkylation and iodolactonization

Hong Sik Moon, Shawn W E Eisenberg, Mark E. Wilson, Neil E. Schore, Mark J. Kurth

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The effective dual use of a chiral auxiliary in two sequential steps is reported; this sequent auxiliary mediates diastereoselective C-C bond formation in the first step and mediates diastereoselective heterocyclization in the second step.

Original languageEnglish (US)
Pages (from-to)6504-6505
Number of pages2
JournalJournal of Organic Chemistry
Volume59
Issue number22
StatePublished - 1994

ASJC Scopus subject areas

  • Organic Chemistry

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