Preoperative and intraoperative predictors of positive margins after breast-conserving surgery: A retrospective review

Payam Saadai, Manijeh Moezzi, Tehillah Menes

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Background: Breast-conserving therapy is an established treatment for early breast cancer. Current practice mandates reoperation for positive margins. Presently most patients are brought to the operating room with a diagnosis of breast cancer made on core biopsy. Preoperative and intraoperative predictors of margin status are needed. Methods: A retrospective review of patients with adenocarcinoma proven on core biopsy undergoing breastconserving surgery between 2000 and 2007. Clinical, radiographic, pathological, and operative data were collected. These were correlated with margin status on excision. Results: One hundred twenty-seven patients met the inclusion criteria. Predictors of positive margins at lumpectomy were younger age, larger size on imaging, calcifications on mammography, multifocality, ductal carcinoma in situ (DCIS) or necrosis on core biopsy, and close margins on specimen films. Conclusions: In the era of preoperative diagnosis of breast cancer with core biopsy, several pre- and intraoperative predictors of positive margins are identified that can aid the surgeon in surgical planning.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalBreast Cancer
Volume18
Issue number3
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Keywords

  • Breast cancer
  • Breast-conserving surgery
  • Core biopsy
  • Margin

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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