Preneoplastic lesions in the human breast

Hanne M Jensen, J. R. Rice, S. R. Wellings

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

A subgross sampling technique with histological confirmation was used to study the pathology of 119 whole human breasts, either cancer-associated (that is, containing cancer or contralateral to a cancer) or taken from random routine autopsies. Atypical lobules were observed much more frequently in the cancer-associated group than in the group of routine autopsy breasts. Atypical lobules showed varying degrees of anaplasia that formed a continuum between normal epithelium and carcinoma in situ, usually of the common ductal type. As apparent markers for increased cancer risk, atypical lobules in the human breast may be homologous to hyperplastic alveolar nodules that are abundant in high mammary cancer strains of mice. This indirect evidence supports the hypothesis that atypical lesions are common preneoplastic lesions in the human mammary gland.

Original languageEnglish (US)
Pages (from-to)295-297
Number of pages3
JournalScience
Volume191
Issue number4224
StatePublished - 1976

ASJC Scopus subject areas

  • General

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