Prenatal phenol and paraben exposures in relation to child neurodevelopment including autism spectrum disorders in the MARBLES study

Jacqueline M. Barkoski, Stefanie A. Busgang, Moira Bixby, Deborah Bennett, Rebecca J. Schmidt, Dana Boyd Barr, Parinya Panuwet, Chris Gennings, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

Abstract

Background: Environmental phenols and parabens are endocrine disrupting chemicals (EDCs) with the potential to affect child neurodevelopment including autism spectrum disorders (ASD). Our aim was to assess whether exposure to environmental phenols and parabens during pregnancy was associated with an increased risk of clinical ASD or other nontypical development (non-TD). Methods: This study included mother-child pairs (N = 207) from the Markers of Autism Risks in Babies – Learning Early Signs (MARBLES) Cohort Study with urinary phenol and paraben metabolites analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) from repeated pregnancy urine samples. Because family recurrence risks in siblings are about 20%, MARBLES enrolls pregnant women who already had a child with ASD. Children were clinically assessed at 3 years of age and classified into 3 outcome categories: ASD, non-TD, or typically developing (TD). Single analyte analyses were conducted with trinomial logistic regression and weighted quantile sum (WQS) regression was used to test for mixture effects. Results: Regression models were adjusted for pre-pregnancy body mass index, prenatal vitamin use (yes/no), homeowner status (yes/no), birth year, and child's sex. In single chemical analyses phenol exposures were not significantly associated with child's diagnosis. Mixture analyses using trinomial WQS regression showed a significantly increased risk of non-TD compared to TD (OR = 1.58, 95% CI: 1.04, 2.04) with overall greater prenatal phenol and paraben metabolites mixture. Results for ASD also showed an increased risk, but it was not significant. Discussion: This is the first study to provide evidence that pregnancy environmental phenol exposures may increase the risk for non-TD in a high-risk population.

Original languageEnglish (US)
Article number108719
JournalEnvironmental Research
Volume179
DOIs
StatePublished - Dec 2019

Fingerprint

Parabens
Autistic Disorder
Phenol
phenol
learning
Learning
pregnancy
Pregnancy
Phenols
Environmental Exposure
Metabolites
metabolite
Endocrine Disruptors
homeowner
Autism Spectrum Disorder
marker
exposure
Liquid chromatography
Tandem Mass Spectrometry
vitamin

Keywords

  • Autism
  • Cohort study
  • Epidemiology
  • Parabens
  • Phenols

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Prenatal phenol and paraben exposures in relation to child neurodevelopment including autism spectrum disorders in the MARBLES study. / Barkoski, Jacqueline M.; Busgang, Stefanie A.; Bixby, Moira; Bennett, Deborah; Schmidt, Rebecca J.; Barr, Dana Boyd; Panuwet, Parinya; Gennings, Chris; Hertz-Picciotto, Irva.

In: Environmental Research, Vol. 179, 108719, 12.2019.

Research output: Contribution to journalArticle

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abstract = "Background: Environmental phenols and parabens are endocrine disrupting chemicals (EDCs) with the potential to affect child neurodevelopment including autism spectrum disorders (ASD). Our aim was to assess whether exposure to environmental phenols and parabens during pregnancy was associated with an increased risk of clinical ASD or other nontypical development (non-TD). Methods: This study included mother-child pairs (N = 207) from the Markers of Autism Risks in Babies – Learning Early Signs (MARBLES) Cohort Study with urinary phenol and paraben metabolites analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) from repeated pregnancy urine samples. Because family recurrence risks in siblings are about 20{\%}, MARBLES enrolls pregnant women who already had a child with ASD. Children were clinically assessed at 3 years of age and classified into 3 outcome categories: ASD, non-TD, or typically developing (TD). Single analyte analyses were conducted with trinomial logistic regression and weighted quantile sum (WQS) regression was used to test for mixture effects. Results: Regression models were adjusted for pre-pregnancy body mass index, prenatal vitamin use (yes/no), homeowner status (yes/no), birth year, and child's sex. In single chemical analyses phenol exposures were not significantly associated with child's diagnosis. Mixture analyses using trinomial WQS regression showed a significantly increased risk of non-TD compared to TD (OR = 1.58, 95{\%} CI: 1.04, 2.04) with overall greater prenatal phenol and paraben metabolites mixture. Results for ASD also showed an increased risk, but it was not significant. Discussion: This is the first study to provide evidence that pregnancy environmental phenol exposures may increase the risk for non-TD in a high-risk population.",
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AU - Bennett, Deborah

AU - Schmidt, Rebecca J.

AU - Barr, Dana Boyd

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