Prenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals

Veronica Martinez-Cerdeno, Jasmin Camacho, Elizabeth Fox, Elaine Miller, Jeanelle Ariza, Devon Kienzle, Kaela Plank, Stephen C Noctor, Judith A Van de Water

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Autism spectrum disorders (ASDs) affect up to 1 in 68 children. Autism-specific autoantibodies directed against fetal brain proteins have been found exclusively in a subpopulation of mothers whose children were diagnosed with ASD or maternal autoantibody-related autism. We tested the impact of autoantibodies on brain development in mice by transferring human antigen-specific IgG directly into the cerebral ventricles of embryonic mice during cortical neurogenesis. We show that autoantibodies recognize radial glial cells during development. We also show that prenatal exposure to autism-specific maternal autoantibodies increased stem cell proliferation in the subventricular zone (SVZ) of the embryonic neocortex, increased adult brain size and weight, and increased the size of adult cortical neurons. We propose that prenatal exposure to autism-specific maternal autoantibodies directly affects radial glial cell development and presents a viable pathologic mechanism for the maternal autoantibody-related prenatal ASD risk factor.

Original languageEnglish (US)
Pages (from-to)374-383
Number of pages10
JournalCerebral Cortex
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Autistic Disorder
Autoantibodies
Mothers
Brain
Ependymoglial Cells
Fetal Proteins
Cerebral Ventricles
Lateral Ventricles
Neocortex
Neurogenesis
Stem Cells
Immunoglobulin G
Cell Proliferation
Neurons
Antigens
Weights and Measures
Autism Spectrum Disorder

Keywords

  • autism
  • brain size
  • maternal autoantibody
  • neurogenesis
  • radial glial cells

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

Cite this

Prenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals. / Martinez-Cerdeno, Veronica; Camacho, Jasmin; Fox, Elizabeth; Miller, Elaine; Ariza, Jeanelle; Kienzle, Devon; Plank, Kaela; Noctor, Stephen C; Van de Water, Judith A.

In: Cerebral Cortex, Vol. 26, No. 1, 01.01.2016, p. 374-383.

Research output: Contribution to journalArticle

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