Prenatal and perinatal risk factors for autism in China

Xin Zhang, Cong Chao Lv, Jiang Tian, Ru Juan Miao, Wei Xi, Irva Hertz-Picciotto, Lihong Qi

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

We conducted a case-control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (<35 or >42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old).

Original languageEnglish (US)
Pages (from-to)1311-1321
Number of pages11
JournalJournal of Autism and Developmental Disorders
Volume40
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • Autism
  • China
  • Perinatal
  • Prenatal
  • Risk factors

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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