Prenatal alcohol exposure attenuates pentylenetetrazol-induced convulsions in rats

Ernest L. Abel, Robert F Berman, Michael W. Church

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Female rats prenatally exposed to alcohol were tested at 35 days of age for susceptibility to pentylenetetrazol (PTZ)-induced convulsions. There was a significant dose-response effect of PTZ. Contrary to expectations, alcohol-exposed females were slightly but still significantly less convulsion-prone than pair-fed controls. These results suggest prenatal alcohol exposure reduces the susceptibility to convulsions in rats.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalAlcohol
Volume10
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Convulsions
  • Pentylenetetrazol
  • Prenatal alcohol
  • Rats

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

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