Abstract
Pregnant Sprague-Dawley rats consumed an ethanol-containing liquid diet containing 0%, 17.5% or 35% ethanol-derived calories (EDC) from gestation day 8 until parturition. A fourth group was fed standard rat chow as an ad lib diet control. Animals prenatally exposed to ethanol had lower birth weights and impaired passive avoidance learning at 17 days of age. At 90 days of age synaptic potentials in area CA1 were characterized electrophysiologically in hippocampal slices. Slices from ethanol-exposed rats had significantly greater paired-pulse facilitation compared to 0% EDC and ad lib controls. Histological examination of brains from litter mates did not indicate altered number, density or nuclear volumes for neurons in area CA1. These data indicate that prenatal ethanol exposure can result in abnormal hippocampal synaptic physiology and suggest that these changes may contribute to the learning impairments observed in rats following such exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 507-511 |
| Number of pages | 5 |
| Journal | Alcohol |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1990 |
| Externally published | Yes |
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Keywords
- Hippocampal slice electrophysiology
- Hippocampus
- Long-term potentiation
- Passive avoidance
- Prenatal alcohol exposure
ASJC Scopus subject areas
- Biochemistry
- Medicine(all)
- Neuroscience(all)
- Behavioral Neuroscience
- Toxicology
- Health(social science)
Cite this
Prenatal alcohol exposure alters hippocampal slice electrophysiology. / Tan, S. E.; Berman, Robert F; Abel, E. L.; Zajac, C. S.
In: Alcohol, Vol. 7, No. 6, 1990, p. 507-511.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prenatal alcohol exposure alters hippocampal slice electrophysiology
AU - Tan, S. E.
AU - Berman, Robert F
AU - Abel, E. L.
AU - Zajac, C. S.
PY - 1990
Y1 - 1990
N2 - Pregnant Sprague-Dawley rats consumed an ethanol-containing liquid diet containing 0%, 17.5% or 35% ethanol-derived calories (EDC) from gestation day 8 until parturition. A fourth group was fed standard rat chow as an ad lib diet control. Animals prenatally exposed to ethanol had lower birth weights and impaired passive avoidance learning at 17 days of age. At 90 days of age synaptic potentials in area CA1 were characterized electrophysiologically in hippocampal slices. Slices from ethanol-exposed rats had significantly greater paired-pulse facilitation compared to 0% EDC and ad lib controls. Histological examination of brains from litter mates did not indicate altered number, density or nuclear volumes for neurons in area CA1. These data indicate that prenatal ethanol exposure can result in abnormal hippocampal synaptic physiology and suggest that these changes may contribute to the learning impairments observed in rats following such exposure.
AB - Pregnant Sprague-Dawley rats consumed an ethanol-containing liquid diet containing 0%, 17.5% or 35% ethanol-derived calories (EDC) from gestation day 8 until parturition. A fourth group was fed standard rat chow as an ad lib diet control. Animals prenatally exposed to ethanol had lower birth weights and impaired passive avoidance learning at 17 days of age. At 90 days of age synaptic potentials in area CA1 were characterized electrophysiologically in hippocampal slices. Slices from ethanol-exposed rats had significantly greater paired-pulse facilitation compared to 0% EDC and ad lib controls. Histological examination of brains from litter mates did not indicate altered number, density or nuclear volumes for neurons in area CA1. These data indicate that prenatal ethanol exposure can result in abnormal hippocampal synaptic physiology and suggest that these changes may contribute to the learning impairments observed in rats following such exposure.
KW - Hippocampal slice electrophysiology
KW - Hippocampus
KW - Long-term potentiation
KW - Passive avoidance
KW - Prenatal alcohol exposure
UR - http://www.scopus.com/inward/record.url?scp=0025188782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025188782&partnerID=8YFLogxK
U2 - 10.1016/0741-8329(90)90040-J
DO - 10.1016/0741-8329(90)90040-J
M3 - Article
C2 - 2261088
AN - SCOPUS:0025188782
VL - 7
SP - 507
EP - 511
JO - Alcohol
JF - Alcohol
SN - 0741-8329
IS - 6
ER -