Abstract
1. Phodopus sungorus. the Siberian dwarf hamster, exhibits an unusual set of behavioral changes when the members of a male-female pair bond are separated. 2. Quantification of these behaviors reveals a significant increase in body weight, decrease in social interactions, and decrease in exploratory behaviors, predominantly in separated males. 3. Preliminary data on antidepressant treatments to reverse the separation syndrome, and on neurochemical changes during the separation period, are presented. 4. Separation of pair-bonded Siberian dwarf hamsters may provide a new animal model for depression, incorporating the practical advantages of a rodent model with the conceptual advantages of a naturalistic life event precipitant.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 447-457 |
| Number of pages | 11 |
| Journal | Progress in Neuropsychopharmacology and Biological Psychiatry |
| Volume | 8 |
| Issue number | 3 |
| State | Published - 1984 |
| Externally published | Yes |
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Keywords
- antidepressants
- behavior model
- catecholamines
- depression
- dwarf hamsters
ASJC Scopus subject areas
- Pharmacology
- Biological Psychiatry
Cite this
Preliminary report of a new rodent separation model of depression. / Crawley, Jacqueline.
In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 8, No. 3, 1984, p. 447-457.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preliminary report of a new rodent separation model of depression
AU - Crawley, Jacqueline
PY - 1984
Y1 - 1984
N2 - 1. Phodopus sungorus. the Siberian dwarf hamster, exhibits an unusual set of behavioral changes when the members of a male-female pair bond are separated. 2. Quantification of these behaviors reveals a significant increase in body weight, decrease in social interactions, and decrease in exploratory behaviors, predominantly in separated males. 3. Preliminary data on antidepressant treatments to reverse the separation syndrome, and on neurochemical changes during the separation period, are presented. 4. Separation of pair-bonded Siberian dwarf hamsters may provide a new animal model for depression, incorporating the practical advantages of a rodent model with the conceptual advantages of a naturalistic life event precipitant.
AB - 1. Phodopus sungorus. the Siberian dwarf hamster, exhibits an unusual set of behavioral changes when the members of a male-female pair bond are separated. 2. Quantification of these behaviors reveals a significant increase in body weight, decrease in social interactions, and decrease in exploratory behaviors, predominantly in separated males. 3. Preliminary data on antidepressant treatments to reverse the separation syndrome, and on neurochemical changes during the separation period, are presented. 4. Separation of pair-bonded Siberian dwarf hamsters may provide a new animal model for depression, incorporating the practical advantages of a rodent model with the conceptual advantages of a naturalistic life event precipitant.
KW - antidepressants
KW - behavior model
KW - catecholamines
KW - depression
KW - dwarf hamsters
UR - http://www.scopus.com/inward/record.url?scp=0021178196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021178196&partnerID=8YFLogxK
M3 - Article
C2 - 6541359
AN - SCOPUS:0021178196
VL - 8
SP - 447
EP - 457
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 3
ER -