Preliminary molecular characterization of a human immunodeficiency virus (HIV-I) associated with neuropathology

R. Anand; A. Srinivasan; M. B. Gardner; Paul A Luciw; Satya Dandekar

Preliminary molecular characterization of a human immunodeficiency virus (HIV-I) associated with neuropathology

R. Anand, A. Srinivasan, M. B. Gardner, Paul A Luciw, Satya Dandekar

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Abstract

A human immunodeficiency virus (HIV-I) was isolated from the brain of a patient with progressive dementia but no obvious immunosuppression. This isolate, designated as HIV-I(BR), was molecularly cloned and sequenced, and its long terminal repeat (LTR) and envelope sequences were compared with those of other HIV isolates not uniquely associated with dementia. The HIV-I(BR) LTR showed marked homology with the LTR sequences of the other HIV-I isolates. The predicted amino acid sequence of the external glycoprotein (gp120) of HIV-I(BR) revealed a pattern of conserved and variable regions similar to that of other HIV isolates. The sequences of the transmembrane portion of envelope, gp41, was highly homologous to the counterpart region of other isolates. Further analysis is required to determine whether specific sequence variation can account for neurological manifestations of HIV-I(BR) infection.

Original language	English (US)
Journal	Annals of Neurology
Volume	23
Issue number	SUPPL.
State	Published - 1988

ASJC Scopus subject areas

Neuroscience(all)

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title = "Preliminary molecular characterization of a human immunodeficiency virus (HIV-I) associated with neuropathology",

abstract = "A human immunodeficiency virus (HIV-I) was isolated from the brain of a patient with progressive dementia but no obvious immunosuppression. This isolate, designated as HIV-I(BR), was molecularly cloned and sequenced, and its long terminal repeat (LTR) and envelope sequences were compared with those of other HIV isolates not uniquely associated with dementia. The HIV-I(BR) LTR showed marked homology with the LTR sequences of the other HIV-I isolates. The predicted amino acid sequence of the external glycoprotein (gp120) of HIV-I(BR) revealed a pattern of conserved and variable regions similar to that of other HIV isolates. The sequences of the transmembrane portion of envelope, gp41, was highly homologous to the counterpart region of other isolates. Further analysis is required to determine whether specific sequence variation can account for neurological manifestations of HIV-I(BR) infection.",

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T1 - Preliminary molecular characterization of a human immunodeficiency virus (HIV-I) associated with neuropathology

AU - Anand, R.

AU - Srinivasan, A.

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AU - Luciw, Paul A

AU - Dandekar, Satya

PY - 1988

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N2 - A human immunodeficiency virus (HIV-I) was isolated from the brain of a patient with progressive dementia but no obvious immunosuppression. This isolate, designated as HIV-I(BR), was molecularly cloned and sequenced, and its long terminal repeat (LTR) and envelope sequences were compared with those of other HIV isolates not uniquely associated with dementia. The HIV-I(BR) LTR showed marked homology with the LTR sequences of the other HIV-I isolates. The predicted amino acid sequence of the external glycoprotein (gp120) of HIV-I(BR) revealed a pattern of conserved and variable regions similar to that of other HIV isolates. The sequences of the transmembrane portion of envelope, gp41, was highly homologous to the counterpart region of other isolates. Further analysis is required to determine whether specific sequence variation can account for neurological manifestations of HIV-I(BR) infection.

AB - A human immunodeficiency virus (HIV-I) was isolated from the brain of a patient with progressive dementia but no obvious immunosuppression. This isolate, designated as HIV-I(BR), was molecularly cloned and sequenced, and its long terminal repeat (LTR) and envelope sequences were compared with those of other HIV isolates not uniquely associated with dementia. The HIV-I(BR) LTR showed marked homology with the LTR sequences of the other HIV-I isolates. The predicted amino acid sequence of the external glycoprotein (gp120) of HIV-I(BR) revealed a pattern of conserved and variable regions similar to that of other HIV isolates. The sequences of the transmembrane portion of envelope, gp41, was highly homologous to the counterpart region of other isolates. Further analysis is required to determine whether specific sequence variation can account for neurological manifestations of HIV-I(BR) infection.

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