Preliminary investigation of ultrasound scattering analysis to identify women at risk for later invasive cancer. I: Motivation and experimental technique for characterization of isolated breast tissue lobules

Thomas M. Burke, Tikoes A. Blankenberg, Albert K Q Siu, Francis G. Blankenberg, Hanne M Jensen

Research output: Contribution to journalArticle

5 Scopus citations


A new experimental technique is described that allows the characterization of the angle-dependent ultrasonic scattering properties of isolated breast tissue lobules. A review of breast tissue micro-architecture is presented as background material. Measured estimates of the scatter angle-dependent differential scatter cross-sections (DSC) from 31 excised lobules (14 cancer in situ, 17 noncancer) were examined, and dominant trends described by statistical factors. Three factors were extracted, using principal component factor analysis, which collectively accounted for over 70% of the scatter angle-dependent variation exhibited by the measured data.

Original languageEnglish (US)
Pages (from-to)295-303
Number of pages9
JournalUltrasound in Medicine and Biology
Issue number3
StatePublished - 1995



  • Acoustic scatterer
  • Angle-dependent scatter
  • Breast tissue lobules
  • Tissue micro-architecture

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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