Abstract
Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 725-732 |
| Number of pages | 8 |
| Journal | Neurobiology of Aging |
| Volume | 24 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2003 |
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Keywords
- Estrogen
- Hippocampus
- MRI
- Neuroprotection1
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
Preliminary evidence that estrogen protects against age-related hippocampal atrophy. / Eberling, J. L.; Wu, C.; Haan, M. N.; Mungas, Dan M; Buonocore, M.; Jagust, W. J.
In: Neurobiology of Aging, Vol. 24, No. 5, 09.2003, p. 725-732.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preliminary evidence that estrogen protects against age-related hippocampal atrophy
AU - Eberling, J. L.
AU - Wu, C.
AU - Haan, M. N.
AU - Mungas, Dan M
AU - Buonocore, M.
AU - Jagust, W. J.
PY - 2003/9
Y1 - 2003/9
N2 - Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen.
AB - Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen.
KW - Estrogen
KW - Hippocampus
KW - MRI
KW - Neuroprotection1
UR - http://www.scopus.com/inward/record.url?scp=0041883787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041883787&partnerID=8YFLogxK
U2 - 10.1016/S0197-4580(02)00056-8
DO - 10.1016/S0197-4580(02)00056-8
M3 - Article
C2 - 12885580
AN - SCOPUS:0041883787
VL - 24
SP - 725
EP - 732
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 5
ER -