Preliminary evidence that estrogen protects against age-related hippocampal atrophy

J. L. Eberling, C. Wu, M. N. Haan, Dan M Mungas, M. Buonocore, W. J. Jagust

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen.

Original languageEnglish (US)
Pages (from-to)725-732
Number of pages8
JournalNeurobiology of Aging
Volume24
Issue number5
DOIs
StatePublished - Sep 2003

Fingerprint

Estrogen Replacement Therapy
Atrophy
Estrogens
Neuroprotective Agents

Keywords

  • Estrogen
  • Hippocampus
  • MRI
  • Neuroprotection1

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Preliminary evidence that estrogen protects against age-related hippocampal atrophy. / Eberling, J. L.; Wu, C.; Haan, M. N.; Mungas, Dan M; Buonocore, M.; Jagust, W. J.

In: Neurobiology of Aging, Vol. 24, No. 5, 09.2003, p. 725-732.

Research output: Contribution to journalArticle

Eberling, J. L. ; Wu, C. ; Haan, M. N. ; Mungas, Dan M ; Buonocore, M. ; Jagust, W. J. / Preliminary evidence that estrogen protects against age-related hippocampal atrophy. In: Neurobiology of Aging. 2003 ; Vol. 24, No. 5. pp. 725-732.
@article{607460a56b8e4521a125ac2cb497f34b,
title = "Preliminary evidence that estrogen protects against age-related hippocampal atrophy",
abstract = "Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen.",
keywords = "Estrogen, Hippocampus, MRI, Neuroprotection1",
author = "Eberling, {J. L.} and C. Wu and Haan, {M. N.} and Mungas, {Dan M} and M. Buonocore and Jagust, {W. J.}",
year = "2003",
month = "9",
doi = "10.1016/S0197-4580(02)00056-8",
language = "English (US)",
volume = "24",
pages = "725--732",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Preliminary evidence that estrogen protects against age-related hippocampal atrophy

AU - Eberling, J. L.

AU - Wu, C.

AU - Haan, M. N.

AU - Mungas, Dan M

AU - Buonocore, M.

AU - Jagust, W. J.

PY - 2003/9

Y1 - 2003/9

N2 - Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen.

AB - Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen.

KW - Estrogen

KW - Hippocampus

KW - MRI

KW - Neuroprotection1

UR - http://www.scopus.com/inward/record.url?scp=0041883787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041883787&partnerID=8YFLogxK

U2 - 10.1016/S0197-4580(02)00056-8

DO - 10.1016/S0197-4580(02)00056-8

M3 - Article

C2 - 12885580

AN - SCOPUS:0041883787

VL - 24

SP - 725

EP - 732

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 5

ER -