Preliminary characterization of a serum viral inhibitor in goats.

Tilahun Yilma, S. Owens, D. S. Adams

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A serum viral inhibitor (SVI) was isolated from goats and partially characterized. The inhibitor prevented the cytopathic effects of vesicular stomatitis virus, encephalomyocarditis virus, and a caprine herpesvirus, indicating broad antiviral activity. The SVI was distinct from interferon because SVI did not induce an antiviral state in cells (ie, lack of protection of SVI-treated cells from virus challenge). The SVI had activity on heterologous cells, including human, bovine, and ovine cells. The lack of antiviral activity in mouse cells indicated that SVI was not an antibody. Like fibroblast interferon, however, SVI was sensitive to trypsin, was acid stable at pH 2 and 4 C for 4 days, was heat stable at 56 C for 1 hour, and could not be sedimented by centrifugation at 100,000 X g for 4 hours.

Original languageEnglish (US)
Pages (from-to)2360-2362
Number of pages3
JournalAmerican Journal of Veterinary Research
Volume46
Issue number11
StatePublished - Nov 1985
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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