90Y and 111In have been attached to chimeric monoclonal antibody L6 with a bifunctional chelating agent (DOTA-peptide isothiocyanate). The bifunctional chelating agent was prelabeled with either radiometal and then conjugated to the antibody. Studies in human patients showed excellent 111In single-photon emission computed tomography images of breast cancer lesions 24 h after injection.
|Original language||English (US)|
|Issue number||23 SUPPL.|
|State||Published - 1995|
ASJC Scopus subject areas
- Cancer Research