Pregnancy-associated colon and rectal cancer: Perinatal and cancer outcomes

Mary T. Dahling, Guibo Xing, Rosemary D Cress, Beate Danielsen, Lloyd H Smith

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective. Assess the impact of colorectal cancer on maternal and neonatal outcomes. Methods. Cases were identified using several computer-generated linkage analyses. Maternal and newborn hospital discharges in California were linked to birth and if applicable infant death certificate records. This database was then linked to the California Cancer Registry, to create a cohort of women with pregnancy-associated colon and rectal cancer. This cohort was compared to pregnant women in California without colorectal cancer. Our secondary comparison was to non-pregnant, Californian women with colorectal cancer who could be aged-matched. Results. Women with pregnancy-associated colorectal cancer were more likely to undergo cesarean section OR: 1.9 and to develop puerperal infections OR: 2.8. In addition, higher rates of preterm delivery were found both secondary to scheduled deliveries and preterm labor OR for preterm labor, 2.8. Neonatal outcomes were fairly similar between the two groups. Pregnancy was not found to have a significant effect on survival HR: 0.73. Conclusions. We found that women with pregnancy-associated colorectal cancer had excellent maternal and neonatal outcomes. This is likely secondary to the fact that most women are diagnosed after delivery. In addition, survival is similar between pregnancy-associated and non-pregnancy associated cases.

Original languageEnglish (US)
Pages (from-to)204-211
Number of pages8
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume22
Issue number3
DOIs
StatePublished - 2009

Fingerprint

Rectal Neoplasms
Colonic Neoplasms
Colorectal Neoplasms
Pregnancy
Death Certificates
Premature Obstetric Labor
Mothers
Neoplasms
Puerperal Infection
Survival
Cesarean Section
Registries
Pregnant Women
Parturition
Newborn Infant
Databases

Keywords

  • Cancer outcomes
  • Colorectal cancer
  • Obstetrical outcomes
  • Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Pregnancy-associated colon and rectal cancer : Perinatal and cancer outcomes. / Dahling, Mary T.; Xing, Guibo; Cress, Rosemary D; Danielsen, Beate; Smith, Lloyd H.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 22, No. 3, 2009, p. 204-211.

Research output: Contribution to journalArticle

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