Prefrontal cortex white matter tracts in prodromal Huntington disease

PREDICT-HD Investigators and Coordinators of the Huntington Study Group

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Huntington disease (HD) is most widely known for its selective degeneration of striatal neurons but there is also growing evidence for white matter (WM) deterioration. The primary objective of this research was to conduct a large-scale analysis using multisite diffusion-weighted imaging (DWI) tractography data to quantify diffusivity properties along major prefrontal cortex WM tracts in prodromal HD. Fifteen international sites participating in the PREDICT-HD study collected imaging and neuropsychological data on gene-positive HD participants without a clinical diagnosis (i.e., prodromal) and gene-negative control participants. The anatomical prefrontal WM tracts of the corpus callosum (PFCC), anterior thalamic radiations (ATRs), inferior fronto-occipital fasciculi (IFO), and uncinate fasciculi (UNC) were identified using streamline tractography of DWI. Within each of these tracts, tensor scalars for fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity coefficients were calculated. We divided prodromal HD subjects into three CAG-age product (CAP) groups having Low, Medium, or High probabilities of onset indexed by genetic exposure. We observed significant differences in WM properties for each of the four anatomical tracts for the High CAP group in comparison to controls. Additionally, the Medium CAP group presented differences in the ATR and IFO in comparison to controls. Furthermore, WM alterations in the PFCC, ATR, and IFO showed robust associations with neuropsychological measures of executive functioning. These results suggest long-range tracts essential for cross-region information transfer show early vulnerability in HD and may explain cognitive problems often present in the prodromal stage.

Original languageEnglish (US)
Pages (from-to)3717-3732
Number of pages16
JournalHuman Brain Mapping
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2015

Fingerprint

Huntington Disease
Prefrontal Cortex
Age Groups
Radiation
Prodromal Symptoms
Corpus Striatum
Nerve Degeneration
Diffusion Tensor Imaging
Corpus Callosum
Anisotropy
Genes
White Matter
Research

Keywords

  • Cross-sectional analysis
  • Diffusion tensor imaging
  • Diffusion tractography
  • Diffusion weighted MRI
  • Huntington's disease
  • Multicenter studies
  • Prefrontal cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2015). Prefrontal cortex white matter tracts in prodromal Huntington disease. Human Brain Mapping, 36(10), 3717-3732. https://doi.org/10.1002/hbm.22835

Prefrontal cortex white matter tracts in prodromal Huntington disease. / PREDICT-HD Investigators and Coordinators of the Huntington Study Group.

In: Human Brain Mapping, Vol. 36, No. 10, 01.10.2015, p. 3717-3732.

Research output: Contribution to journalArticle

PREDICT-HD Investigators and Coordinators of the Huntington Study Group 2015, 'Prefrontal cortex white matter tracts in prodromal Huntington disease', Human Brain Mapping, vol. 36, no. 10, pp. 3717-3732. https://doi.org/10.1002/hbm.22835
PREDICT-HD Investigators and Coordinators of the Huntington Study Group. Prefrontal cortex white matter tracts in prodromal Huntington disease. Human Brain Mapping. 2015 Oct 1;36(10):3717-3732. https://doi.org/10.1002/hbm.22835
PREDICT-HD Investigators and Coordinators of the Huntington Study Group. / Prefrontal cortex white matter tracts in prodromal Huntington disease. In: Human Brain Mapping. 2015 ; Vol. 36, No. 10. pp. 3717-3732.
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KW - Multicenter studies

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