Prefrontal cortex hemodynamics and age: A pilot study using functional near infrared spectroscopy in children

Afrouz A. Anderson, Elizabeth Smith, Victor Chernomordik, Yasaman Ardeshirpour, Fatima Chowdhry, Audrey Thurm, David Black, Dennis L Matthews, Owen Rennert, Amir H. Gandjbakhche

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cerebral hemodynamics reflect cognitive processes and underlying physiological processes, both of which are captured by functional near infrared spectroscopy (fNIRS). Here, we introduce a novel parameter of Oxygenation Variability directly obtained from fNIRS data -the OV Index-and we demonstrate its use in children. fNIRS data were collected from 17 children (ages 4-8 years), while they performed a standard Go/No-Go task. Data were analyzed using two frequency bands-the first attributed to cerebral autoregulation (CA) (<0.1 Hz) and the second to respiration (0.2-0.3 Hz). Results indicate differences in variability of oscillations of oxygen saturation (SO2) between the two different bands. These pilot data reveal a dynamic relationship between chronological age and OV index in CA associated frequency of <0.1 Hz. Specifically, OV index increased with age between 4 and 6 years. In addition, there was much higher variability in frequencies associated with CA than for respiration across subjects. These findings provide preliminary evidence for the utility of the OV index and are the first to describe the relationship between cerebral autoregulation and age in children using fNIRS methodology.

Original languageEnglish (US)
Article number393
JournalFrontiers in Neuroscience
Volume8
Issue numberDEC
DOIs
StatePublished - 2014

Fingerprint

Near-Infrared Spectroscopy
Prefrontal Cortex
Homeostasis
Hemodynamics
Respiration
Physiological Phenomena
Oxygen

Keywords

  • Autoregulation
  • Functional near infrared spectroscopy
  • Hemodynamic model

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Anderson, A. A., Smith, E., Chernomordik, V., Ardeshirpour, Y., Chowdhry, F., Thurm, A., ... Gandjbakhche, A. H. (2014). Prefrontal cortex hemodynamics and age: A pilot study using functional near infrared spectroscopy in children. Frontiers in Neuroscience, 8(DEC), [393]. https://doi.org/10.3389/fnins.2014.00393

Prefrontal cortex hemodynamics and age : A pilot study using functional near infrared spectroscopy in children. / Anderson, Afrouz A.; Smith, Elizabeth; Chernomordik, Victor; Ardeshirpour, Yasaman; Chowdhry, Fatima; Thurm, Audrey; Black, David; Matthews, Dennis L; Rennert, Owen; Gandjbakhche, Amir H.

In: Frontiers in Neuroscience, Vol. 8, No. DEC, 393, 2014.

Research output: Contribution to journalArticle

Anderson, AA, Smith, E, Chernomordik, V, Ardeshirpour, Y, Chowdhry, F, Thurm, A, Black, D, Matthews, DL, Rennert, O & Gandjbakhche, AH 2014, 'Prefrontal cortex hemodynamics and age: A pilot study using functional near infrared spectroscopy in children', Frontiers in Neuroscience, vol. 8, no. DEC, 393. https://doi.org/10.3389/fnins.2014.00393
Anderson, Afrouz A. ; Smith, Elizabeth ; Chernomordik, Victor ; Ardeshirpour, Yasaman ; Chowdhry, Fatima ; Thurm, Audrey ; Black, David ; Matthews, Dennis L ; Rennert, Owen ; Gandjbakhche, Amir H. / Prefrontal cortex hemodynamics and age : A pilot study using functional near infrared spectroscopy in children. In: Frontiers in Neuroscience. 2014 ; Vol. 8, No. DEC.
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