Prefrontal cortex gating of auditory transmission in humans

Robert T. Knight, Donatella Scabini, David L Woods

Research output: Contribution to journalArticlepeer-review

212 Scopus citations


Middle-latency auditory evoked potentials (MAEPs) were recorded in controls and patients with focal lesions in dorsalateral prefrontal cortex. Unilateral prefrontal lesions increased the amplitude of the Pa component of the MAEP beginning at 25-35 ms poststimulus. The data suggest that prefrontal cortex exerts early inhibitory modulation of input to primary auditory cortex in humans.

Original languageEnglish (US)
Pages (from-to)338-342
Number of pages5
JournalBrain Research
Issue number2
StatePublished - Dec 18 1989


  • Attention
  • Gating
  • Inhibition
  • Middle-latency auditory evoked potential
  • Pa
  • Prefrontal

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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