Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning

Howard J. Aizenstein, Meryl A. Butters, Kristi A. Clark, Jennifer L. Figurski, V. Andrew Stenger, Robert D. Nebes, Charles F. Reynolds, Cameron S Carter

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Decreased function in the prefrontal cortex (PFC) is regarded as a primary mechanism of cognitive aging. However, despite a strong association between the prefrontal cortex and the neostriatum, the role of the neostriatum in cognitive aging is less certain. In the current study, event-related functional MRI was used to distinguish the cognitive contributions of neostriatal and prefrontal function in elderly versus young subjects. Twenty healthy subjects, 9 elderly (mean age 67.6 years), and 11 young (mean age 22 years) performed a concurrent implicit and explicit sequence learning task while undergoing functional MR imaging. Both groups showed learning in both the implicit and explicit task conditions. Relative to the young subjects, the elderly subjects showed decreased activation in the left PFC during both implicit and explicit learning, decreased activation in the right putamen during implicit learning, and increased activation in the right PFC during explicit learning. Our results support the theory that changes in a network of brain regions, including the dorsolateral prefrontal cortex and the striatum, are related to cognitive aging. Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness.

Original languageEnglish (US)
Pages (from-to)741-751
Number of pages11
JournalNeurobiology of Aging
Volume27
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

Fingerprint

Corpus Striatum
Prefrontal Cortex
Learning
Neostriatum
Putamen
Healthy Volunteers
Magnetic Resonance Imaging
Brain
Cognitive Aging

Keywords

  • Aging
  • fMRI
  • Implicit learning
  • Prefrontal cortex
  • Sequence learning
  • Serial reaction-time
  • Striatum

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning. / Aizenstein, Howard J.; Butters, Meryl A.; Clark, Kristi A.; Figurski, Jennifer L.; Andrew Stenger, V.; Nebes, Robert D.; Reynolds, Charles F.; Carter, Cameron S.

In: Neurobiology of Aging, Vol. 27, No. 5, 05.2006, p. 741-751.

Research output: Contribution to journalArticle

Aizenstein, HJ, Butters, MA, Clark, KA, Figurski, JL, Andrew Stenger, V, Nebes, RD, Reynolds, CF & Carter, CS 2006, 'Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning', Neurobiology of Aging, vol. 27, no. 5, pp. 741-751. https://doi.org/10.1016/j.neurobiolaging.2005.03.017
Aizenstein, Howard J. ; Butters, Meryl A. ; Clark, Kristi A. ; Figurski, Jennifer L. ; Andrew Stenger, V. ; Nebes, Robert D. ; Reynolds, Charles F. ; Carter, Cameron S. / Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning. In: Neurobiology of Aging. 2006 ; Vol. 27, No. 5. pp. 741-751.
@article{921b252020d04ccc94ec65d3c2b54e70,
title = "Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning",
abstract = "Decreased function in the prefrontal cortex (PFC) is regarded as a primary mechanism of cognitive aging. However, despite a strong association between the prefrontal cortex and the neostriatum, the role of the neostriatum in cognitive aging is less certain. In the current study, event-related functional MRI was used to distinguish the cognitive contributions of neostriatal and prefrontal function in elderly versus young subjects. Twenty healthy subjects, 9 elderly (mean age 67.6 years), and 11 young (mean age 22 years) performed a concurrent implicit and explicit sequence learning task while undergoing functional MR imaging. Both groups showed learning in both the implicit and explicit task conditions. Relative to the young subjects, the elderly subjects showed decreased activation in the left PFC during both implicit and explicit learning, decreased activation in the right putamen during implicit learning, and increased activation in the right PFC during explicit learning. Our results support the theory that changes in a network of brain regions, including the dorsolateral prefrontal cortex and the striatum, are related to cognitive aging. Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness.",
keywords = "Aging, fMRI, Implicit learning, Prefrontal cortex, Sequence learning, Serial reaction-time, Striatum",
author = "Aizenstein, {Howard J.} and Butters, {Meryl A.} and Clark, {Kristi A.} and Figurski, {Jennifer L.} and {Andrew Stenger}, V. and Nebes, {Robert D.} and Reynolds, {Charles F.} and Carter, {Cameron S}",
year = "2006",
month = "5",
doi = "10.1016/j.neurobiolaging.2005.03.017",
language = "English (US)",
volume = "27",
pages = "741--751",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning

AU - Aizenstein, Howard J.

AU - Butters, Meryl A.

AU - Clark, Kristi A.

AU - Figurski, Jennifer L.

AU - Andrew Stenger, V.

AU - Nebes, Robert D.

AU - Reynolds, Charles F.

AU - Carter, Cameron S

PY - 2006/5

Y1 - 2006/5

N2 - Decreased function in the prefrontal cortex (PFC) is regarded as a primary mechanism of cognitive aging. However, despite a strong association between the prefrontal cortex and the neostriatum, the role of the neostriatum in cognitive aging is less certain. In the current study, event-related functional MRI was used to distinguish the cognitive contributions of neostriatal and prefrontal function in elderly versus young subjects. Twenty healthy subjects, 9 elderly (mean age 67.6 years), and 11 young (mean age 22 years) performed a concurrent implicit and explicit sequence learning task while undergoing functional MR imaging. Both groups showed learning in both the implicit and explicit task conditions. Relative to the young subjects, the elderly subjects showed decreased activation in the left PFC during both implicit and explicit learning, decreased activation in the right putamen during implicit learning, and increased activation in the right PFC during explicit learning. Our results support the theory that changes in a network of brain regions, including the dorsolateral prefrontal cortex and the striatum, are related to cognitive aging. Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness.

AB - Decreased function in the prefrontal cortex (PFC) is regarded as a primary mechanism of cognitive aging. However, despite a strong association between the prefrontal cortex and the neostriatum, the role of the neostriatum in cognitive aging is less certain. In the current study, event-related functional MRI was used to distinguish the cognitive contributions of neostriatal and prefrontal function in elderly versus young subjects. Twenty healthy subjects, 9 elderly (mean age 67.6 years), and 11 young (mean age 22 years) performed a concurrent implicit and explicit sequence learning task while undergoing functional MR imaging. Both groups showed learning in both the implicit and explicit task conditions. Relative to the young subjects, the elderly subjects showed decreased activation in the left PFC during both implicit and explicit learning, decreased activation in the right putamen during implicit learning, and increased activation in the right PFC during explicit learning. Our results support the theory that changes in a network of brain regions, including the dorsolateral prefrontal cortex and the striatum, are related to cognitive aging. Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness.

KW - Aging

KW - fMRI

KW - Implicit learning

KW - Prefrontal cortex

KW - Sequence learning

KW - Serial reaction-time

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=33645998419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645998419&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2005.03.017

DO - 10.1016/j.neurobiolaging.2005.03.017

M3 - Article

C2 - 15935517

AN - SCOPUS:33645998419

VL - 27

SP - 741

EP - 751

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 5

ER -