Prefrontal and striatal activation during sequence learning in geriatric depression

Howard J. Aizenstein, Meryl A. Butters, Jennifer L. Figurski, V. Andrew Stenger, Charles F. Reynolds, Cameron S Carter

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Background: Frontostriatal dysfunction is a primary hypothesis for the neurocognitive changes of depression in late life. The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits. Methods: Twenty-three elderly subjects (mean age, 69.9 years) participated: 11 subjects with a current major depressive episode and 12 nondepressed elderly control subjects. Subjects underwent fMRI while performing a concurrent implicit and explicit sequence learning task. Region of interest (ROI)-based analyses were conducted, focusing on the dorsal anterior cingulate cortex, the dorsolateral prefrontal cortex, and the neostriatum. Results: As expected, both the control and depressed subjects learned the sequence during both implicit and explicit conditions. During explicit learning, decreased prefrontal activation was found in the depressed subjects, along with increased striatal activation. The increased striatal activity in the depressed subjects was due to increased activity on the trials that violated the sequence. During implicit learning, no significant differences were found between the groups in the identified ROIs. Conclusions: The increased striatal activation on trials that violated the sequence demonstrates a greater response to negative feedback for depressed compared with control subjects. Our observations of significant differences in both prefrontal and striatal regions in the depressed elderly subjects relative to elderly control subjects supports the frontostriatal dysfunction hypothesis of late-life depression.

Original languageEnglish (US)
Pages (from-to)290-296
Number of pages7
JournalBiological Psychiatry
Volume58
Issue number4
DOIs
StatePublished - Aug 15 2005

Fingerprint

Corpus Striatum
Geriatrics
Learning
Depression
Magnetic Resonance Imaging
Neostriatum
Gyrus Cinguli
Prefrontal Cortex

Keywords

  • Aging
  • Depression
  • fMRI
  • Implicit learning
  • Prefrontal cortex
  • Sequence learning
  • Serial reaction time
  • Striatum

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Aizenstein, H. J., Butters, M. A., Figurski, J. L., Stenger, V. A., Reynolds, C. F., & Carter, C. S. (2005). Prefrontal and striatal activation during sequence learning in geriatric depression. Biological Psychiatry, 58(4), 290-296. https://doi.org/10.1016/j.biopsych.2005.04.023

Prefrontal and striatal activation during sequence learning in geriatric depression. / Aizenstein, Howard J.; Butters, Meryl A.; Figurski, Jennifer L.; Stenger, V. Andrew; Reynolds, Charles F.; Carter, Cameron S.

In: Biological Psychiatry, Vol. 58, No. 4, 15.08.2005, p. 290-296.

Research output: Contribution to journalArticle

Aizenstein, HJ, Butters, MA, Figurski, JL, Stenger, VA, Reynolds, CF & Carter, CS 2005, 'Prefrontal and striatal activation during sequence learning in geriatric depression', Biological Psychiatry, vol. 58, no. 4, pp. 290-296. https://doi.org/10.1016/j.biopsych.2005.04.023
Aizenstein, Howard J. ; Butters, Meryl A. ; Figurski, Jennifer L. ; Stenger, V. Andrew ; Reynolds, Charles F. ; Carter, Cameron S. / Prefrontal and striatal activation during sequence learning in geriatric depression. In: Biological Psychiatry. 2005 ; Vol. 58, No. 4. pp. 290-296.
@article{8c1729f9799842ef9cf80e5ff52475e9,
title = "Prefrontal and striatal activation during sequence learning in geriatric depression",
abstract = "Background: Frontostriatal dysfunction is a primary hypothesis for the neurocognitive changes of depression in late life. The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits. Methods: Twenty-three elderly subjects (mean age, 69.9 years) participated: 11 subjects with a current major depressive episode and 12 nondepressed elderly control subjects. Subjects underwent fMRI while performing a concurrent implicit and explicit sequence learning task. Region of interest (ROI)-based analyses were conducted, focusing on the dorsal anterior cingulate cortex, the dorsolateral prefrontal cortex, and the neostriatum. Results: As expected, both the control and depressed subjects learned the sequence during both implicit and explicit conditions. During explicit learning, decreased prefrontal activation was found in the depressed subjects, along with increased striatal activation. The increased striatal activity in the depressed subjects was due to increased activity on the trials that violated the sequence. During implicit learning, no significant differences were found between the groups in the identified ROIs. Conclusions: The increased striatal activation on trials that violated the sequence demonstrates a greater response to negative feedback for depressed compared with control subjects. Our observations of significant differences in both prefrontal and striatal regions in the depressed elderly subjects relative to elderly control subjects supports the frontostriatal dysfunction hypothesis of late-life depression.",
keywords = "Aging, Depression, fMRI, Implicit learning, Prefrontal cortex, Sequence learning, Serial reaction time, Striatum",
author = "Aizenstein, {Howard J.} and Butters, {Meryl A.} and Figurski, {Jennifer L.} and Stenger, {V. Andrew} and Reynolds, {Charles F.} and Carter, {Cameron S}",
year = "2005",
month = "8",
day = "15",
doi = "10.1016/j.biopsych.2005.04.023",
language = "English (US)",
volume = "58",
pages = "290--296",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Prefrontal and striatal activation during sequence learning in geriatric depression

AU - Aizenstein, Howard J.

AU - Butters, Meryl A.

AU - Figurski, Jennifer L.

AU - Stenger, V. Andrew

AU - Reynolds, Charles F.

AU - Carter, Cameron S

PY - 2005/8/15

Y1 - 2005/8/15

N2 - Background: Frontostriatal dysfunction is a primary hypothesis for the neurocognitive changes of depression in late life. The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits. Methods: Twenty-three elderly subjects (mean age, 69.9 years) participated: 11 subjects with a current major depressive episode and 12 nondepressed elderly control subjects. Subjects underwent fMRI while performing a concurrent implicit and explicit sequence learning task. Region of interest (ROI)-based analyses were conducted, focusing on the dorsal anterior cingulate cortex, the dorsolateral prefrontal cortex, and the neostriatum. Results: As expected, both the control and depressed subjects learned the sequence during both implicit and explicit conditions. During explicit learning, decreased prefrontal activation was found in the depressed subjects, along with increased striatal activation. The increased striatal activity in the depressed subjects was due to increased activity on the trials that violated the sequence. During implicit learning, no significant differences were found between the groups in the identified ROIs. Conclusions: The increased striatal activation on trials that violated the sequence demonstrates a greater response to negative feedback for depressed compared with control subjects. Our observations of significant differences in both prefrontal and striatal regions in the depressed elderly subjects relative to elderly control subjects supports the frontostriatal dysfunction hypothesis of late-life depression.

AB - Background: Frontostriatal dysfunction is a primary hypothesis for the neurocognitive changes of depression in late life. The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits. Methods: Twenty-three elderly subjects (mean age, 69.9 years) participated: 11 subjects with a current major depressive episode and 12 nondepressed elderly control subjects. Subjects underwent fMRI while performing a concurrent implicit and explicit sequence learning task. Region of interest (ROI)-based analyses were conducted, focusing on the dorsal anterior cingulate cortex, the dorsolateral prefrontal cortex, and the neostriatum. Results: As expected, both the control and depressed subjects learned the sequence during both implicit and explicit conditions. During explicit learning, decreased prefrontal activation was found in the depressed subjects, along with increased striatal activation. The increased striatal activity in the depressed subjects was due to increased activity on the trials that violated the sequence. During implicit learning, no significant differences were found between the groups in the identified ROIs. Conclusions: The increased striatal activation on trials that violated the sequence demonstrates a greater response to negative feedback for depressed compared with control subjects. Our observations of significant differences in both prefrontal and striatal regions in the depressed elderly subjects relative to elderly control subjects supports the frontostriatal dysfunction hypothesis of late-life depression.

KW - Aging

KW - Depression

KW - fMRI

KW - Implicit learning

KW - Prefrontal cortex

KW - Sequence learning

KW - Serial reaction time

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=23644436532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23644436532&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2005.04.023

DO - 10.1016/j.biopsych.2005.04.023

M3 - Article

C2 - 16018981

AN - SCOPUS:23644436532

VL - 58

SP - 290

EP - 296

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 4

ER -